Repeated high dose (5.0 mg/kg) anabolic/androgenic steroid exposure during adolescence stimulates offensive aggression in male Syrian hamsters. These studies examined whether anabolic/androgenic steroid-induced aggression was regulated by the activity and expression of serotonin (5HT) type-1A receptors. In a first experiment, adolescent male hamsters were treated with a mixture of anabolic/andr...

Some of the effects that high-dose anabolic steroid abuse have and could have on the interactions between the immune and neuroendocrine systems are reviewed. Considering the past demonstrations on the actions of normal steroids on endocrine and immune responses, it is apparent that pharmacologically high doses of both normal and derivatized androgens (anabolic steroids) could have a significant...

12 Brower K, Eliopulos GA, Blow FC, Catlin DH, Beresford TP. Evidence for physical and psychological dependence on anabolic androgenic steroids in eight weight lifter. Am J Psychiatry 1990;147:510-2. 13 Bahrke MS, Wright JE, Strauss RH, Catlin DH. Psychological moods and subjectivity perceived behavioural and somatic changes accompanying anabolic-androgenic steroid use. AmJSports Med 1993:20:71...

Ischemic stroke among young people is an infrequent and rare entity. Despite the existence of a long list etiologies, progressive imposition ideal body image in society represents another cause ischemic stroke. To this end, bodybuilding practices have been imposed on large part adolescent sector with intense exercise routines accompanied by supplementation anabolic-androgenic steroids (AAS). Ab...

Use of anabolic steroids has for some time been widespread among competitive sportsmen and women, who selfadminister doses of up to 100 times the recommended therapeutic dose, and use combinations of multiple oral and injectable preparations (a practice known as'stacking'). Often these are preparations intended for veterinary use, or of questionable origin, purity or authenticity. They are take...

BACKGROUND Alcohol is one of the most common causes of liver disease in the Western World today. Randomised clinical trials have examined the effects of anabolic-androgenic steroids for alcoholic liver disease. OBJECTIVES The objectives were to assess the beneficial and harmful effects of anabolic-androgenic steroids for patients with alcoholic liver disease based on the results of randomised...

In addition to the pharmacological side effects of anabolic steroids, complications may also result from the injection technique used in self administration. Two cases are presented where anabolic steroid injections resulted in knee joint sepsis and radial nerve palsy.

BACKGROUND Anabolic steroids have the clinical effect of increasing protein synthesis in muscle and other tissues. The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord. CASE REPORT We evaluated the effect of Oxandrolone (an FDA-a...

Metabolism of steroid hormones with anabolic properties was studied in vitro using human recombinant CYP3A4, CYP2C9 and 2B6 enzymes. The enzyme formats used for CYP3A4 and CYP2C9 were insect cell microsomes expressing human CYP enzymes and purified recombinant human CYP enzymes in a reconstituted system. CYP3A4 enzyme formats incubated with anabolic steroids, testosterone, 17alpha-methyltestost...

Anabolic steroids form one of the important classes of doping agents and their consumption has been found to give benefits to the athletes. Inspite of the fact that they also produce adverse effects and damage several organs and systems, their consumption is continuously increasing in competitive games. The World Anti-Doping Agency and International Olympic Committee have banned the use of anab...