نتایج جستجو برای: amsterdam ii criteria
تعداد نتایج: 832174 فیلتر نتایج به سال:
BACKGROUND The mutational spectrum of mismatch repair (MMR) genes in the Baltic States has been reported to be quite similar to that in Poland; however during a country-wide study considerable differences in the population of Latvia were discovered. This study was undertaken to investigate the clinical and molecular features of HNPCC in Latvia. MATERIALS AND METHODS Family cancer histories we...
1Clinic for Dermatology, DermaPark, Uden, Netherlands; 2Department of Internal Medicine, Kennemergasthuis, Haarlem, Netherlands; 3Department of Dermatology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, Netherlands; 4STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, Netherlands; 5Centre for Infection and Immunity Amsterdam (CINIMA), Academic Medical Cente...
BACKGROUND Family history is important for identifying candidates for high risk cancer screening and referral for genetic counseling. We sought to determine the percentage of individuals who would be eligible for high risk cancer screening or genetic referral and testing if family history includes an extended (vs limited) family history. METHODS Family histories were obtained from 626 women a...
To determine the role of methylation in colorectal cancer patients with a family history, we enrolled 25 colorectal cancer patients with a family history of colorectal cancer but without a mutation in the hMLH1 and hMSH2 genes. Thirty patients with sporadic colorectal cancer were included as control. The methylation status of COX2, MGMT, hMLH1, TIMP3, p16, and MINT2 in normal mucosa and tumor w...
Background: Identifying Lynch syndrome (LS) in patients with colorectal cancer (CRC) and monitoring their relatives can increase the life expectancy of these patients. Objectives: The aim this study was to analyze cost-effectiveness 5 molecular testing strategies screen LS among newly diagnosed CRC conduct preventive surveillance first-degree relatives. Methods: A decision tree model designed i...
J.M. MAASKANT, msc, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, J.P. De BOER, phd, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, O. DALESIO, msc, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, M.J. HOLTKAMP, manp, Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, & C. LUCAS, phd, Dep...
Johannes D. de Boer, Lea C. Berkhout, Sacha F. de Stoppelaar, Jack Yang, Roelof Ottenhoff, Joost C. M. Meijers, Joris J. T. H. Roelofs, Cornelis van’t Veer, and Tom van der Poll Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, the Netherlands. Department of Medical Biochemistry, Academic Medical Center...
Gerdien E. de Kloe, Jeroen Kool, Rene van Elk, Jacqueline E. van Muijlwijk-Koezen, August B. Smit, Henk Lingeman, Hubertus Irth, Wilfried M.A. Niessen and Iwan J.P. de Esch Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands, Leiden/Amsterdam Center for Drug Resear...
Germline mutations in the DNA mismatch repair genes MSH2 and MLH1 account for a significant proportion of hereditary non-polyposis colorectal cancer (HNPCC) families. One approach by which development of an efficient DNA-testing procedure can be implemented is to describe the nature and frequency of common mutations in particular ethnic groups. Two hundred and twenty-six patients from families ...
The criteria for the diagnosis of HNPCC established by the ICG-HNPCC are very restrictive as they do not allow for the diagnosis of a large number of “suspected HNPCC“ cases – these are families which do no fulfill the strict diagnostic “Amsterdam criteria“, but do present with several pedigree and clinical features characteristic for HNPCC. Several series of families suspected of harboring ger...
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