Antibody-mediated rejection (AMR) is gaining increasing recognition as a major complication after heart transplantation, posing a significant risk for allograft failure, cardiac allograft vasculopathy, and poor survival. AMR results from activation of the humoral immune arm and the production of donor-specific antibodies (DSA) that bind to the cardiac allograft causing myocardial injury predomi...

Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies to non-HLA antigens in AMR and allograft injury. Despite the remarkable efforts by leaders in the field who pioneered single antigen bead tech...

We describe our submission system to the SemEval-2016 Task 8 on Abstract Meaning Representation (AMR) Parsing. We attempt to improve AMR parsing by exploiting preposition semantic role labeling information retrieved from a multi-layer feed-forward neural network. Prepositional semantics is included as features into the transition-based AMR parsing system CAMR (Wang, Xue, and S. Pradhan 2015a). ...

In this paper, a time warping algorithm is implemented and its performance is evaluated in the context of Adaptive MultiRate (AMR) wideband (WB) and narrowband (NB) speech coders. The aim of time warping is to achieve bit savings in transmission of pitch information with no significant quality degradations. In the case of AMR-NB and AMR-WB speech coders, these bit savings are 0.65-1.15 kbit/s d...

This paper describes the Adaptive Multirate Wideband (AMR-WB) speech codec recently selected by the Third Generation Partnership Project (3GPP) for GSM and the third generation mobile communication WCDMA system for providing wideband speech services. The AMR-WB speech codec algorithm was selected in December 2000 and the corresponding specifications were approved in March 2001. The AMR-WB codec...

OBJECTIVES Antimicrobial resistance (AMR) threatens our ability to treat the sexually transmitted bacterial infection gonorrhoea. The increasing availability of whole genome sequence (WGS) data from Neisseria gonorrhoeae isolates, however, provides us with an opportunity in which WGS can be mined for AMR determinants. METHODS Chromosomal and plasmid genes implicated in AMR were catalogued on ...

Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. Despite the general acceptance of the usefulness of C4d in the ...

We agree with the recent report in this Journal from Nand and colleagues that education is a key factor in curbing antimicrobial resistance (AMR). AMR is a leading patient health and safety issue that requires engagement at all levels of society. Although there is commitment from clinicians practicing infection-related specialties towards research in AMR and antimicrobial stewardship (AMS), the...

For numerical simulation of detonation, computational cost using uniform meshes is large due to the vast separation in both time and space scales. Adaptive mesh refinement (AMR) is advantageous for problems with vastly different scales. This paper aims to propose an AMR method with high order accuracy for numerical investigation of multi-dimensional detonation. A well-designed AMR method based ...

Transplant rejection is the critical clinical end-point limiting indefinite survival after histocompatibility antigen (HLA) mismatched organ transplantation. The predominant cause of late graft loss is antibody-mediated rejection (AMR), a process whereby injury to the organ is caused by donor-specific antibodies, which bind to HLA and non-HLA (nHLA) antigens. AMR is incompletely diagnosed as do...