نتایج جستجو برای: amp activated protein kinase
تعداد نتایج: 1505784 فیلتر نتایج به سال:
Members of the AMP-activated protein kinase family, including the Snf1 kinase of Saccharomyces cerevisiae, are activated under conditions of nutrient stress. AMP-activated protein kinases are heterotrimeric complexes composed of a catalytic alpha subunit and regulatory beta and gamma subunits. In this study, the role of the beta subunits in the regulation of Snf1 activity was examined. Yeasts e...
OVERCOMING TUMOR DRUG RESISTANCE BY ACTIVATING AMP-ACTIVATED PROTEIN KINASE AND DESTABILIZING ONCOPROTEINS
CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown. However, their importance was underlined by findings that mutations in conserved residues within them cause a variety of human hereditary diseases, including (with the gene mutated in parentheses): Wolff-Parkinso...
Hormone-sensitive lipase partially purified from adipose tissue of laying hens was markedly activated by cyclic AMP-dependent protein kinase. Activation was approximately 4-fold (ranging up to as great as 10-fold) compared with the much lower degree of activation obtained with analogous preparations from rat and human adipose tissues (59 and 86%, respectively). The partially purified preparatio...
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Activation in response to increas...
The AMP-activated protein kinase has been purified by affinity chromatography on ATP-gamma-Sepharose. A proportion of the activity can be eluted using AMP, while the remainder is eluted using ATP. The AMP eluate contains three polypeptides of 63, 38 and 35 kDa (p63, p38 and p35) in a molar ratio (by Coomassie blue binding) close to 1:1:1. p63 was previously identified as the AMP-binding catalyt...
conclusions according to the results, ud is able to decrease glucose level and improve insulin release in t2dm. in addition, as ud is able to induce a small increase in ampk activity, it is possible that the anti-hyperglycemic effect of ud is mediated by insulin secretion and the possible changes in ampk levels. results fbg levels of the drug group were significantly decreased compared with the...
468 The Journal of Clinical Investigation http://www.jci.org Volume 114 Number 4 August 2004 and injury. J. Clin. Invest. 114:495–503. doi:10.1172/ JCI200419297. 9. Mu, J., Brozinick, J.T., Valladares, O., Bucan, M., and Birnbaum, M.J. 2001. A role for AMP-activated protein kinase in contractionand hypoxia-regulated glucose transport in skeletal muscle. Mol. Cell. 7:1085–1094. 10. Hudson, E.R.,...
A protein kinase, which was produced from its proenzyme occurring in rat brain upon limited proteolysis by a Ca2+-dependent protease from the same tissue (Inoue, M., Kishimoto, A., Takai, Y., and Nishizlka, Y. (1977) J. Biol. Chem. 252, 7610-7616, was capable of phosphorylating alpha and beta subunits of rabbit skeletal muscle glycogen phosphorylase kinase, resulting in a marked enhancement of ...
BACKGROUND Low plasma high-density lipoprotein (HDL) is associated with elevated cardiovascular risk and aspects of the metabolic syndrome. We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle. METHODS AND RESULTS Thirteen patients with type 2 diabet...
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