A sensitive, simple and rapid RP-HPLC method with fluorescence detection has been developed to simultaneously quantify amlodipine besylate (AML) olmesartan medoxomil (OLM) in their combined pharmaceutical preparation. The development was divided into three phases. In the first phase, a Plackett-Burman design (PBD) used screen five independent factors. objective of second phase optimize performa...

BACKGROUND Optimal first-step antihypertensive drug therapy in type 2 diabetes mellitus (DM) or impaired fasting glucose levels (IFG) is uncertain. We wished to determine whether treatment with a calcium channel blocker or an angiotensin-converting enzyme inhibitor decreases clinical complications compared with treatment with a thiazide-type diuretic in DM, IFG, and normoglycemia (NG). METHOD...

Neurology. 2017 Jul 18;89(3):e20. doi: 10.1212/WNL.0000000000004116. Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. Uniyal R(1), Paliwal VK(2), Kumar N(2), Malhotra HS(2), Garg RK(2), Neyaz Z(2). Author information: (1)From the Department of . Find patient medical information for Amlodipine Oral on WebMD including its uses, side effec...

OBJECTIVE To assess the effect of amlodipine and atorvastatin on intercellular adhesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-α expression, as endothelial function and inflammation indicators, respectively, in hypertensive patients with and without prediabetes. METHODS Forty-five consecutive patients with hypertension, diagnosed according to JNC7, were divided into two groups base...

Mucoadhesive chitosan microspheres of amlodipine besylate were prepared for nasal administration with the aim of avoiding the first pass effect. A series of batches of microspheres were prepared by simple emulsification crosslinking method to optimize parameters like external phase (mixture of heavy and light liquid paraffin in the ratio of 1:1), stirring rate (1200 rpm), dioctyl sodium sulfosu...

Olmesartan medoxamil (OLM, an angiotensin II receptor blocker), amlodipine besylate (AML, a dihydropyridine calcium channel blocker) and hydrochlorothiazide (HCT, a diuretic of the class of benzothiadiazines) are co-formulated in a single-dose combination for the treatment of hypertensive patients whose blood pressure is not adequately controlled on either component monotherapy. In this work, t...