The usual supermembrane solution ofD = 11 supergravity interpolates between R11 and AdS4× round S7, has symmetry P3×SO(8) and preserves 1/2 of the spacetime supersymmetries for either orientation of the round S7. Here we show that more general supermembrane solutions may be obtained by replacing the round S7 by any seven-dimensional Einstein space M7. These have symmetry P3 × G, where G is the ...

Cytologic and cytogenetic results obtained from patients fulfilling the FAB criteria for the diagnosis of acute nonlymphocytic leukemia (ANLL) of megakaryocytic lineage (ANLL-M7) are reported. Eleven cases were de novo ANLL-M7, of whom three presented with acute myelofibrosis. Four cases were megakaryoblastic transformations of chronic myelogenous leukemia (two cases), refractory anemia with ex...

Previous studies have shown that influenza virus-immune cytotoxic T lymphocytes can recognize virus in conjunction with self HLA-A2 antigens. Nevertheless, the virus-infected target cells from one HLA-A2-positive male donor (designated M7) could not be lysed by the virus-immune cytotoxic lymphocytes from any HLA-A2-matched unrelated donors. Although extensive serological analyses showed no diff...

Adenovirus 5 vectors, known respectively as, the first generation, second generation and oncolytic adenovirus, have been studied extensively in preclinical and clinical trials. However, hitherto few systemic evaluations of the efficacy and toxicity of these adenoviral vectors that have reflected the vertical history of adenovirus based cancer gene therapy strategies have been undertaken. This s...

BACKGROUND Setipiprant, a tetrahydropyridoindole derivative, is a CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper [Th]-2 cells) antagonist that has the potential to be effective in the treatment of patients with diseases with an allergic etiology, such as allergic rhinitis and asthma. OBJECTIVES This study investigated the disposition, metabolism, and elimination of ...

Brivanib alaninate, the L-alanine ester prodrug of brivanib, is currently being developed as an anticancer agent. In humans, brivanib alaninate is rapidly hydrolyzed to brivanib. Prominent biotransformation pathways of brivanib included oxidation and direct sulfate conjugation. A series of in vitro studies were conducted to identify the human esterases involved in the prodrug hydrolysis and to ...

Gamete-recognition proteins often evolve rapidly, but it is not known if their divergence occurs within species and corresponds with the evolution of reproductive isolation, or if divergence typically accumulates between already isolated lineages. We examined the evolution of a candidate gamete-recognition protein in several sympatric and allopatric populations of Mytilus blue mussels, species ...

Acute myeloid leukemia (AML) constitutes about 15% of childhood (0 to 15 years) acute leukemia in the United Kingdom, with an age-standardized incidence rate of approximately 6 cases/million/yr.1 Although the causes of childhood AML are uncertain, dietary and chemical exposure to substances that inhibit DNA topoisomerase II have been implicated.2,3 However, it is not clear whether genetic susce...

In this note we consider the existence problem for symplectic 3forms on 7-manifolds. We find a first example of a closed 3-form of G̃2-type on S 3 × S4. We also prove that any integral symplectic 3forms on a compact 7-manifold M7 can be obtained by embedding M7 to a universal space (WN , h), where N = N0 +3(80 + 8.C 3 8 )), the number N0 does not depend on M 7. MSC: 53C10, 53C42