BACKGROUND Post-dural puncture headache (PDPH) is the most common complication of lumbar puncture. Aminophylline has been reported to be effective in the prevention of PDPH in some clinical studies, but its efficacy for the treatment of PDPH has been unproven. OBJECTIVE To evaluate the efficacy and safety of an intravenous (IV) injection of aminophylline on PDPH. STUDY DESIGN The study was ...

BACKGROUND Aminophylline therapy in elderly patients with COPD is rarely studied. This study attempted to explore the symptoms, pulmonary function improvement, and adverse events related to aminophylline therapy in COPD patients of different age groups. METHODS AND RESULTS We designed a 10-week prospective study. Two groups of COPD patients were classified based on age (30 patients in group 1...

Aminophylline is a respiratory stimulant commonly used for the treatment of central apnea. Experiences from clinical practice, however, revealed that aminophylline is not reliably effective in preterm infants, whereas it is normally effective in infants and mature patients. In an established animal model for postnatal development of respiratory control mechanisms, we therefore examined the hypo...

274 May 2013, Vol. 103, No. 5 SAMJ Asthma guidelines: Why aminophylline? To the Editor: While it is always encouarging to see new clinical guidelines to help direct therapy for important clinical conditions, the ‘Guidelines for the management of acute asthma in adults’ are disappointing in two regards. Firstly, a majority of acute asthma attacks in adults are managed in the emergency centre and...

The effects of an intracoronary aminophylline infusion, adjusted to give a constant concentration of 25 microgram.cm-3 coronary blood, on the reactive hyperaemic responses following coronary occlusion for 4, 10, and 25 heart beats were investigated in anaesthetised, open-chest dogs. The vasodilator effect of intracoronarily-administered adenosine and the hyperaemic response after coronary occlu...

The effects of β2-agonists and methylxanthines on neutrophil function in vitro. C.G. Llewellyn-Jones, R.A. Stockley. ERS Journals Ltd 1994. ABSTRACT: Therapeutic agents which affect polymorphonuclear neutrophil (PMN) functions have the potential to reduce or increase PMN activation and, hence, influence the progression of lung inflammation. We have assessed the effects of the β2-agonist, terbu...

Intravenous aminophylline is used as a first line treatment for bronchial asthma. This preparation consists of theophylline or a salt of theophylline dissolved in a solution of ethylenediamine, which confers greater solubility and reduces the alkalinity of the drug.1 In clinical usage side effects of tachycardia, seizures and nausea are well known. We report on the much less common, but clinica...

Exercise tolerance in chronic obstructive pulmonary disease (COPD) patients treated with oral aminophylline may be different from those treated with high-dose inhaled ipratropium bromide. The purpose of this study was to compare the effects of therapeutic doses of oral aminophylline with high-dose ipratropium bromide on spirometry and exercise tolerance. The study was conducted on three consecu...

OBJECTIVE Aminophylline, which is clinically used as a bronchodilator, antagonizes the action of adenosine, so it can be used to shorten the recovery time after general anesthesia. Therefore, we wanted to test the hypothesis that the administration of aminophylline leads to an increase in bispectral index (BIS) and clinical recovery in patients anesthetized with total intravenous anesthesia (TI...