Conjugation of siRNA to macromolecules such as serum albumin has multiple potential benefits, including enhanced extravasation via albumin-mediated transcytosis across endothelial cells and reduced renal clearance. In attempting to conjugate siRNA to albumin, we used commercially sourced amine-modified siRNA and reacted it with the heterobifunctional linker succinimidyl 4-[N-maleimidomethyl]cyc...

Small-molecule microarrays composed of tens of thousands of distinct synthetic molecules, natural products, and their combinations/modifications provide a high-throughput platform for studying protein-ligand interactions. Immobilization of small molecule compounds on solid supports remains a challenge as widely varied small molecules generally lack unique chemical groups that readily react with...

Acyclic amine-carboxyboranes were effective anti-inflammatory agents in mice at 8 mg/kg x 2. These amine-carboxyboranes were more effective than the standard indomethacin at 8 mg/kg x 2, pentoxifylline at 50 mg/kg x 2, and phenylbutazone at 50 mg/kg x 2. The heterocyclic amine derivatives as well as amine-carbamoylboranes, carboalkoxyboranes, and cyanoboranes were generally less active. However...

in some special cases, rubber compounds with high amounts of unsaturated elastomer are recommended with organic sulfur donors instead of mineral sulfurs. in this condition, activated sulfur is produced in situ and curingprocess is facilitated without accelerators. organic sulfur donor compounds have low thermal stability and in the vulcanization temperature produce free and activated sulfurs. t...

The unusual fluorescence behavior of the pyridoxal-P coenzyme of phosphorylase b, which shows on excitation at 330 nm a maximal fluorescence emission at 535 nm, could be mimicked by model compounds of pyridoxal-P and various amines in hydrophobic solvents. Study of the model compounds indicated that the pyridoxal-P and the amine initially form a carbinol amine which, upon activation, yields a S...

Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.

1. Inactivation of beta-phenylethylamine and several of its derivatives was studied in a preparation of rabbit lung perfused with Krebs physiological medium at 37 degrees C. Inactivation or removal of these compounds was calculated as the difference between the concentration of each amine in the perfusion medium and the effluent, collected separately from each lung. The extent of amine metaboli...

The heterocyclic compounds are very important part of medicinal chemistry, among them it is worth to pay attention on derivatives of quinazoline. They have a broad spectrum of pharmacological activities like anticancer (1ñ3), anti-HIV (3), antitubercular (4), anti-inflammatory (5), anticonvulsant (6) and antihypertensive activity (7). The most recognized derivatives among quinazolines with anti...

Three moving bed biofilm reactors were used to treat synthesized wastewater of aromatic amine compounds including aniline, para-diaminobenzene and para-aminophenol that are found in many industrial wastewaters. The reactors with cylindrical shape had an internal diameter and an effective depth of 10 and 60 cm, respectively. The reactors were filled with light expanded clay aggregate as carriers...