نتایج جستجو برای: amidine

تعداد نتایج: 368  

Journal: :The Journal of biological chemistry 2005
Bouna-Moussa Tandia Caroline Lonez Michel Vandenbranden Jean-Marie Ruysschaert Abdelatif Elouahabi

It has been previously shown that transfection activity of cationic liposome/DNA lipoplexes delivered systemically is drastically inhibited by lipoproteins (Tandia, B. M., Vandenbranden, M., Wattiez, R., Lakhdar, Z., Ruysschaert, J. M., and Elouahabi, A. (2003) Mol Ther. 8, 264-273). In this work, we have compared the binding/uptake and transfection activities of DOTAP (N-[1-(2,3-dioleoyloxy)pr...

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Journal: :Journal of the American Chemical Society 2009

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Journal: :Antimicrobial agents and chemotherapy 2005
Mhairi L Stewart Cyrille Boussard Reto Brun Ian H Gilbert Michael P Barrett

Single benzamidine group-carrying compounds were shown to interact with the Trypanosoma brucei P2 aminopurine transporter. Replacement of the amidine with a guanidine group decreased affinity. Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 transporter, which indicates additional uptake routes for monobenzamidine-derived compounds.

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Journal: :Angewandte Chemie 1965

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Journal: :Berichte der deutschen chemischen Gesellschaft 1876

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Journal: :Journal of Synthetic Organic Chemistry, Japan 1971

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Journal: :ACS Medicinal Chemistry Letters 2011

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Journal: :Cancer research 2002
Amélie Lansiaux Farial Tanious Zohar Mishal Laurent Dassonneville Arvind Kumar Chad E Stephens Qiyue Hu W David Wilson David W Boykin Christian Bailly

Diphenylfuran diamidines represent an important class of DNA minor groove binders of high therapeutic interest as antiparasitic or antitumor agents depending on the compounds structures. To exert their cytotoxic action, the compounds must first get into the cell and reach the nuclear compartment where the main target, DNA, is located. The forces that drive the drugs into cell nuclei, as well as...

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2014
Dawn M. Makley Jeffrey N. Johnston

We report that N-(trimethylsilyl)imines serve in the Bis(AMidine)-catalyzed addition of bromonitromethane with a high degree of enantioselection. This allows for the production of a range of protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung Amide Synthesis (UmAS). Hence, peptide homologation with nonnatural aryl glycine amino acids is achieved in three steps from aromati...

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2014
Mateo I. Sánchez Cristina Penas M. Eugenio Vázquez José L. Mascareñas

Attachment of alloc protecting groups to the amidine units of fluorogenic DNA-binding bisbenzamidines or to the amino groups of ethidium bromide leads to a significant reduction of their DNA affinity. More importantly, the active DNA-binding species can be readily regenerated by treatment with ruthenium catalysts in aqueous conditions, even in cell cultures. The catalytic chemical uncaging can ...

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