نتایج جستجو برای: alveoli

تعداد نتایج: 2401  

Journal: :Journal of applied physiology 2012
A J Hajari D A Yablonskiy A L Sukstanskii J D Quirk M S Conradi J C Woods

Despite decades of research into the mechanisms of lung inflation and deflation, there is little consensus about whether lung inflation occurs due to the recruitment of new alveoli or by changes in the size and/or shape of alveoli and alveolar ducts. In this study we use in vivo (3)He lung morphometry via MRI to measure the average alveolar depth and alveolar duct radius at three levels of insp...

Journal: :Journal of applied physiology 2010
Steen Andreassen Kristoffer L Steimle Mads L Mogensen Jorge Bernardino de la Serna Stephen Rees Dan S Karbing

This paper presents a novel mathematical model of alveoli, which simulates the effects of tissue elasticity and surfactant on the stability of human alveoli. The model incorporates a spherical approximation to the alveolar geometry, the hysteretic behavior of pulmonary surfactant and tissue elasticity. The model shows that the alveolus without surfactant and the elastic properties of the lung t...

Journal: :Journal of applied physiology 2014
Stefan A Tschanz Lilian A Salm Matthias Roth-Kleiner Sebastien F Barré Peter H Burri Johannes C Schittny

Roughly 90% of the gas-exchange surface is formed by alveolarization of the lungs. To the best of our knowledge, the formation of new alveoli has been followed in rats only by means of morphological description or interpretation of semiquantitative data until now. Therefore, we estimated the number of alveoli in rat lungs between postnatal days 4 and 60 by unambiguously counting the alveolar op...

Journal: :Journal of applied physiology 2013
Toshihiro Sera Hideo Yokota Gaku Tanaka Kentaro Uesugi Naoto Yagi Robert C Schroter

We visualized pulmonary acini in the core regions of the mouse lung in situ using synchrotron refraction-enhanced computed tomography (CT) and evaluated their kinematics during quasi-static inflation. This CT system (with a cube voxel of 2.8 μm) allows excellent visualization of not just the conducting airways, but also the alveolar ducts and sacs, and tracking of the acinar shape and its defor...

2007
Heinz Fehrenbach Robert Voswinckel Verena Michl Tanja Mehling Antonia Fehrenbach Werner Seeger Jens R. Nyengaard

Regeneration of gas exchange area by induction of neoalveolarization would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. We addressed the question whether new alveoli are added to the residual lung after pneumonectomy in mice...

Journal: :The Journal of Cell Biology 1991
N Stelly J P Mauger M Claret A Adoutte

The plasma membrane of Paramecium is underlain by a continuous layer of membrane vesicles known as cortical alveoli, whose function was unknown but whose organization had suggested some resemblance with muscle sarcoplasmic reticulum. The occurrence of antimonate precipitates within the alveoli first indicated to us that they may indeed correspond to a vast calcium storage site. To analyze the p...

Journal: :The Journal of Cell Biology 2001
Keiko Miyoshi Jonathan M. Shillingford Gilbert H. Smith Sandra L. Grimm Kay-Uwe Wagner Takami Oka Jeffrey M. Rosen Gertraud W. Robinson Lothar Hennighausen

Functional development of mammary epithelium during pregnancy depends on prolactin signaling. However, the underlying molecular and cellular events are not fully understood. We examined the specific contributions of the prolactin receptor (PrlR) and the signal transducers and activators of transcription 5a and 5b (referred to as Stat5) in the formation and differentiation of mammary alveolar ep...

2006
Hideo Ichimura Kaushik Parthasarathi Jens Lindert Jahar Bhattacharya

Ichimura, Hideo, Kaushik Parthasarathi, Jens Lindert, and Jahar Bhattacharya. Lung surfactant secretion by interalveolar Ca signaling. Am J Physiol Lung Cell Mol Physiol 291: L596–L601, 2006. First published May 12, 2006; doi:10.1152/ajplung.00036.2006.—Although clusters of alveoli form the acinus, which is the most distal respiratory unit, it is not known whether interalveolar communication co...

Journal: :The European respiratory journal 2008
H Fehrenbach R Voswinckel V Michl T Mehling A Fehrenbach W Seeger J R Nyengaard

Regeneration of the gas exchange area by induction of neoalveolarisation would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. The question of whether new alveoli are added to the residual lung after pneumonectomy in mice was a...

Journal: :The European respiratory journal 2016
Peter J F M Merkus

The way the human lung grows post-natally has intrigued many of us and many of our predecessors, and still does. Originally exclusively based on post mortem findings, it was concluded that a large variability in number of alveoli exists between humans and that this wide scatter is present not only at birth but also in childhood [1, 2]. From these cross-sectional anatomical studies, it could not...

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