When small phosphatidylcholine liposomes are added to perforated cells, they bind preferentially to the Golgi suggesting an exceptional avidity of this organelle for curved membranes without stereospecific interactions. We show that the cis golgin GMAP-210 accounts for this property. First, the liposome tethering properties of the Golgi resembles that of the amphipathic lipid-packing sensor (AL...

High-resolution 32-20 Ma-old stratigraphic records from the Molasse foreland basin situated north of the Alps, and Gonfolite Lombarda conglomerates deposited on the southern Alpine margin, document two consecutive sedimentary responses - an immediate and delayed response - to slab breakoff beneath the central Alps c. 32-30 Ma ago. The first signal, which occurred due to rebound and surface upli...

A three population system with a top predator population, i.e. the herbivores, and two prey populations, grass and trees, is considered to model the interaction of herbivores with natural resources. We apply the model for four natural mountain parks in Northern Italy, three located in the Eastern Alps, two of which in the Dolomites and one in the Julian Alps, and one in the Maritime Alps, North...

To reduce the problem of premature convergence we define a new method for measuring an individual’s age and propose the Age-Layered Population Structure (ALPS). This measure of age measures how long the genetic material has been evolving in the population: offspring start with an age of 1 plus the age of their oldest parent instead of starting with an age of 0 as with traditional measures of ag...

Autoimmune diseases (ADs) have close relationship with the onset of malignant lymphoma. They closely tie to lymphoma. Immune disorders might play an important role in transformation from ADs to lymphoma. DLBCL occurred after autoimmune hematological diseases and autoimmune lymphoproliferative syndrome (ALPS) was rare. The interval between ADs and DLBCL was long and the pathogenesis might be rel...

We describe a girl, now 9 years of age, with chronic idiopathic thrombocytopenic purpura, persistent nonmalignant lymphadenopathy, splenomegaly, recurrent infections, and autoimmune hemolytic anemia. Her symptoms partly fit the definitions of both autoimmune lymphoproliferative syndrome (ALPS) and common variable immunodeficiency disorders (CVIDs). Genetic analysis showed no abnormalities in th...

De novo protein sequencing is one of the key problems in mass spectrometry-based proteomics, especially for novel proteins such as monoclonal antibodies for which genome information is often limited or not available. However, due to limitations in peptides fragmentation and coverage, as well as ambiguities in spectra interpretation, complete de novo assembly of unknown protein sequences still r...

Cognitive Tutors are proven effective learning environments, but are still not as effective as one-on-one human tutoring. We describe an environment (ALPS) designed to engage students in question-asking during problem solving. ALPS integrates Cognitive Tutors with Synthetic Interview (SI) technology, allowing students to type free-form questions and receive pre-recorded video clip answers. We p...

[1] Thirty new 100‐year records of glacier surface mass balance, accumulation and melt in the Swiss Alps are presented. The time series are based on a comprehensive set of field data and distributed modeling and provide insights into the glacier‐climate linkage. Considerable mass loss over the 20th century is evident for all glaciers, but rates differ strongly. Glacier mass loss shows multideca...

A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(-)CD8(-) (double-negative [DN]) T cells. Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critical roles in effector cell function and memory cell fitness of CD8(+) T lymphocytes. We provide e...