The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...

BACKGROUND AND PURPOSE A linkage between the neurotransmitter alpha-calcitonin gene-related peptide (alpha-CGRP) and particle-induced osteolysis has been shown previously. The suggested osteoprotective influence of alpha-CGRP on the catabolic effects of ultra-high molecular weight polyethylene (UHMWPE) particles is analyzed in this study in primary human osteoblasts. METHODS Primary human ost...

Abstract The Alpha Magnetic Spectrometer, AMS-02, is a magnetic spectrometer detector operating on the International Space Station (ISS) since May 19 th , 2011. More than 200 billion events have been collected by instrument in first 11 years of data taking, providing detailed and novel insights composition energy spectra cosmic rays up to TeV energies. We review most recent AMS-02 measurements ...

background: alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. the biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interaction...

Primary organic aerosol (POA) and associated vapors can play an important role in determining the formation and properties of secondary organic aerosol (SOA). If SOA and POA are miscible, POA will significantly enhance SOA formation and some POA vapor will incorporate into SOA particles. When the two are not miscible, condensation of SOA on POA particles forms particles with complex morphology....

[1] Numerous loose rocks with dimensions of a few centimeters to tens of centimeters and with no obvious physical relationship to outcrop rocks have been observed along the traverse of the Mars Exploration Rover Opportunity. To date, about a dozen of these rocks have been analyzed with Opportunity’s contact instruments, providing information about elemental chemistry (Alpha Particle X‐ray Spect...

1. Mission to Venus Mai-Trinh Pham, Zachary Griggs, Chris Johnson, and Taj Ballinger, Department of Physics and Astronomy The Mission To Venus (MTV) team proposes a planetary mission to: 1) search for evidence of current Venusian volcanic activity; 2) search for specifics about rocks and volcanic activity type at Iduun Mons; 3) identify specifics of Venusian surface structures; in an effort to ...

Mass spectrometry for fundamental studies in metrology and atomic, nuclear and particle physics requires extreme sensitivity and efficiency as well as ultimate resolving power and accuracy. An overview will be given on the global status of high-accuracy mass spectrometry for fundamental physics and metrology. Three quite different examples of modern mass spectrometric experiments in physics are...

A new airborne particle spectrometer has been developed with the same measurement capabilities of the Forward Scattering Spectrometer Probes (FSSP) models 100 and 300 (FSSP-300 and FSSP100), two-dimensional optical imaging probe (2D-OAP), the Multiangle Aerosol Spectrometer Probe (MASP) and hot-wire liquid water probe, but with a single integrated system. The cloud, aerosol and precipitation sp...

We found the alpha-particle priming dose which could effectively induce in vivo radioadaptive response in the embryos of the zebrafish, Danio rerio, to be 4.8e48 mGy, through the apoptotic signals scored in the embryos at 24 h post fertilization. Specially fabricated thin polyallyldiglycol carbonate (PADC) films were used as support substrates for the dechorionated embryos. During irradiation, ...