Background & aims Weight loss after proper diet is one of the main topics in nutrition. This study was designed to evaluate effects probiotic and alpha-Lipoic acid (ALA) supplements on anthropometric indicators maintenance weight overweight individuals. Methods consisted two phases (8 weeks) (16 weeks). Eighty-eight participants were randomly divided into 4 groups phase 1: isocaloric with (500 ...

INTRODUCTION The -lipoic acid (ALA) has been used as a treatment to reduce oxidative damage in Systemic Arterial Hypertension (SAH), but there are no in vivo studies reporting the effect of its mechanism of action on iron metabolism. OBJECTIVE To evaluate the antioxidant effect of -lipoic acid on Blood cell count (CBC) and iron metabolism in hypertensive subjects with or without anemia. M...

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1032-9 Konrad D. Division of Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland. [email protected] Alpha-lipoic acid is a naturally occurring cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant. It can interchange between a reduced form and an oxidized form, thereby displaying reducing (...

BACKGROUND A double-blind placebo-controlled trial was conducted in order to evaluate the efficacy of alpha lipoic acid (ALA) and determine the statistical significance of the outcome variables. Burning mouth syndrome (BMS) is defined as an oral burning sensation in the absence of clinical signs which could justify the syndrome. Recent studies suggest the existence of neurological factors as a ...

We have demonstrated previously the ability of the antioxidant alpha lipoic acid (ALA) to suppress and treat a model of multiple sclerosis (MS), relapsing experimental autoimmune encephalomyelitis (EAE). We describe the effects of ALA and its reduced form, dihydrolipoic acid (DHLA), on the transmigration of human Jurkat T cells across a fibronectin barrier in a transwell system. ALA and DHLA in...

The objective of this study was to determine the effects of alpha lipoic acid on the performance and serum lipid profile in broiler chicken. In this study, eighty, day-old Venn Cobb commercial broiler chicks broiler chicks were randomly distributed into two treatment groups with four replicates of ten birds each and the birds were fed with experimental diets T1 (Control ration as per BIS [1992]...

Th is study was designed to investigate whether inclusions of coenzyme Q10, alpha lipoic acid and their combination into diets of hens improve egg quality characteristics. Forty-eight, 33 weeks old Lohmann Brown hens were assigned randomly to four groups of 12 hens each and fed either a basal diet or basal diet supplemented with 2 g/ kg coenzyme Q10, 0.4 g/kg alpha lipoic acid and 2 g/kg coenzy...

Unlike normal cells, tumor cells survive in a specific redox environment where the elevated reactive oxygen species contribute to enhance cell proliferation and to suppress apoptosis. Alpha-lipoic acid, a naturally occurring reactive oxygen species scavenger, has been shown to possess anticancer activity, due to its ability to suppress proliferation and to induce apoptosis in different cancer c...

Considerable evidence indicates that hyperglycemia increases oxidative stress and contributes to the increased incidence of atherosclerosis and cardiovascular complications in diabetic patients. To examine the effect of alpha-lipoic acid, a potent natural antioxidant, on atherosclerosis in diabetic mice, 3-month-old apolipoprotein (apo) E-deficient (apoE(-/-)) mice were made diabetic by adminis...

Nanoemulsions (NEs) and Lipid Nanoparticles(LNs) are regarded as suitable nanosized carriers of water-insoluble active components such as Alpha Lipoic Acid (ALA), Coenzyme Q10 (CoQ10) and Vitamin E (VE) to improve the physical and chemical stabilities of active components. Good physical and chemical stability of particles was proved by Photon Correlation Spectroscopy (PCS), Laser Diffraction (L...