نتایج جستجو برای: alpha glucosidase

تعداد نتایج: 207190  

Journal: :New biotechnology 2010
Souren Paul Ching Tsang Hou Sun Chul Kang

Microbial conversion of unsaturated fatty acids often leads to special changes in their product structures and in biological potential. In our continuous effort to screen natural products for their antimicrobial and enzyme inhibitor activities, we found that 10-hydroxy-8(E)-octadecenoic acid (HOD) exhibited strong anti-alpha-glucosidase (EC 3.2.1.20) activity. HOD is an intermediate in the bioc...

Journal: :Blood 2010
Niek P van Til Merel Stok Fatima S F Aerts Kaya Monique C de Waard Elnaz Farahbakhshian Trudi P Visser Marian A Kroos Edwin H Jacobs Monique A Willart Pascal van der Wegen Bob J Scholte Bart N Lambrecht Dirk J Duncker Ans T van der Ploeg Arnold J J Reuser Monique M Verstegen Gerard Wagemaker

Pompe disease (acid alpha-glucosidase deficiency) is a lysosomal glycogen storage disorder characterized in its most severe early-onset form by rapidly progressive muscle weakness and mortality within the first year of life due to cardiac and respiratory failure. Enzyme replacement therapy prolongs the life of affected infants and supports the condition of older children and adults but entails ...

2017
Rambabu Gundla Ramesh Garlapati Narender Pottabathini Venkateshwarlu Gurram Kumara Swamy Kasani Chiranjeevi Thulluri Pavan Kumar Machiraju Avinash B. Chaudhary Uma Addepally Raveendra Dayam Venkata Rao Chunduri Nagaraju Madala

To develop a lead anti-diabetic compound, a series of 21 novel quinazoline derivatives have been synthesized and screened against alpha Glucosidase. The binding mode of the compounds at the active site of alpha Glucosidase was explored using Glide docking method. The binding model suggests one to four hydrogen bonding interactions between quinazoline derivatives and alpha-glucosidase. 6-Bromo-2...

Journal: :Biodiversitas 2022

Abstract. Ramadhan R, Phuwapraisirisan P, Amirta Darmawan MFB, Ul-Haq K, Kusuma IW, Suwito H, Abdulgani N, Mukhdlor A, Saparwadi. 2022. The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers. Biodiversitas 23: 2225-2231. Ten plant extracts Kalimantan flora, traditionally used to treat blood sugar levels other diabetes-rel...

2007
Soo-Kyung Lee Ji-Yeon Hwang Ji-Hyun Song Ja-Rim Jo Myung-Jin Kim Mi-Eun Kim Jung-In Kim

The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood glucose levels as close to normal as possible. alpha-Glucosidase is the enzyme that digests dietary carbohydrate, and inhibition of this enzyme could suppress postprandial hyperglycemia. The purpose ...

2009
Yilin Vogel Nikolaus J Buchner Michael Szpakowski Andrea Tannapfel Bernhard F Henning

INTRODUCTION Pneumatosis cystoides intestinalis is characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the intestine. The term pneumatosis cystoides coli is synonymous with pneumatosis cystoides intestinalis when the disorder is limited to the colon. It is a secondary finding caused by a wide variety of underlying gastrointestinal...

Journal: :Microbial Cell Factories 2005
Ha LeThanh Peter Neubauer Frank Hoffmann

BACKGROUND: The permanently impaired protein folding during recombinant protein production resembles the stress encountered at extreme temperatures, under which condition the putative holding chaperones, IbpA/IbpB, play an important role. We evaluated the impact of ibpAB deletion or overexpression on stress responses and the inclusion body metabolism during production of yeast alpha-glucosidase...

Journal: :Diabetic medicine : a journal of the British Diabetic Association 2011
O J Phung N A Sood B E Sill C I Coleman

AIM To determine the comparative efficacy of oral anti-diabetic drugs in preventing the development of Type 2 diabetes. METHODS A systematic literature search of MEDLINE, EMBASE and Cochrane CENTRAL was conducted for randomized controlled trials evaluating oral anti-diabetic drugs in patients at high risk for developing Type 2 diabetes. Mixed-treatment comparison meta-analysis methods were us...

2012
Varsha Ghadyale Shrihari Takalikar Vivek Haldavnekar Akalpita Arvindekar

Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. Cymbopogon martinii (CM) (family Poaceae) is used in traditional Indian medicine in treatment of diabetes mellitus. The alpha glucosidase inhibitory action of the plant is studied. The active component was separated using hot water extraction of the whole plant powder, di...

2012
Natasha Jaiswal Swayam P Srivastava Akansha Mishra Amit K Sonkar Tadigoppula Narender Arvind K Srivastava Akhilesh K Tamrakar

Postprandial hyperglycemia is a prominent and early defect in diabetes and regulating blood glucose elevation may attenuate progression towards diabetes associated secondary complications. Here we investigated the alphaglucosidase inhibitory potential of the ethanolic extract of the stem bark of Acacia nilotica (EEAN). The EEAN showed a remarkable alpha-glucosidase inhibitory effect with IC50 v...

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