In ayurveda, a tradional system of medicine, aloe vera (Aloe Barbadensis) is commonly used in sunburn, minor cuts, insect bites and used as wound healing, anti-inflammatory, antiviral, antitumor, laxative and in the treatment of frostbite and psoriasis. The whole plant as well as its specific parts (leaves, roots), plant extracts and its active constituent mucopolysaccharides [MPS] (long chain ...

The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The t...

The effect of Aloe vera juice in combination with glibenclamide was investigated in diabetic patients. There was no response to glibenclamide alone but Aloe vera juice significantly reduced levels of fasting blood glucose within two weeks and of triglycerides within four weeks. It showed no effect on cholesterol levels and had no toxic effects on kidney or liver function as assessed by blood ch...

This study evaluated the effect of oral Aloe vera juice supplementation on gastric pH, stool specific gravity, protein digestion/absorption, and stool microbiology. Results indicate that supplemental oral Aloe vera juice is well tolerated by most individuals and has favorable effects upon a number of gastrointestinal parameters. A discussion of the potential role of Aloe vera juice on inflammat...

This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for su...

OBJECTIVES Aloe barbadensis miller or Aloe vera has been used for therapeutic purposes since ancient times with antifungal activity known to be amongst its medicinal properties. We conducted a pilot study to determine the antifungal properties of Malaysian Aloe vera leaf extract on otomycosis species including Aspergillus niger and Candida albicans. METHODS This laboratory-controlled prospect...

This study reports on the acute toxic effects of Aloe barbadensis Miller (Aloe vera) juice as well as high doses of the antioxidants vitamin C, vitamin E and TroloxTM (a water soluble vitamin E analogue) to the salt water crustacean Artemia franciscana. Aloe vera juice exposure resulted in acute toxicity, being capable of inducing mortality at dilutions as low as 4 % juice and having an LC50 at...

Aloe vera has been used in traditional herbal medicine as an immunomodulatory agent inducing anti-inflammatory effects. However, its role on the IL-1β inflammatory cytokine production has not been studied. IL-1β production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. In this study we aimed to determine the effect of Aloe ...

Aloe vera gel is increasingly consumed as a beverage dietary supplement. The purpose of this study was to determine potential toxicity of a stabilized aloe vera gel derived from the inner gel fillet and marketed as a drink. The gel juice was assessed through assays of genotoxicity in vivo and acute and subchronic toxicity in B6C3F1 mice. Aloe vera did not increase the SOS DNA repair response in...

Obesity-induced disorders contribute to the development of metabolic diseases such as insulin resistance, fatty liver diseases, and type 2 diabetes (T2D). In this study, we evaluated whether the Aloe QDM complex could improve metabolic disorders related to blood glucose levels and insulin resistance. Male C57BL/6 obese mice fed a high-fat diet for 54 days received a supplement of Aloe QDM compl...