Pharmacopeial recommendations for administration of antimalarial drugs are the same weight-based (mg/kg of body weight) doses for children and adults. However, linear calculations are known to underestimate pediatric doses; therefore, interspecies allometric scaling data may have a role in predicting doses in children. We investigated the allometric scaling relationships of antimalarial drugs u...

The allometric-constraint hypothesis states that evolutionary divergence of morphological traits is restricted by integrated growth regulation. In this study, we test this hypothesis on a time-calibrated and well-documented palaeontological sequence of dental measurements on the Pleistocene arvicoline rodent species Mimomys savini from the Iberian Peninsula. Based on 507 specimens representing ...

The aim of this study was to investigate the influence of MHS genotype on growth and development of muscle and fatty tissue in pig hams. The investigation was performed on 72 barrows divided into 4 groups according to genotype (NN and Nn) and feeding regime (standard and intensive). The data for analyses were collected by MRT imaging; the coefficients of allometric growth were calculated using ...

Theoretical models for allometric relationships between organismal form and function are typically tested by comparing a single predicted relationship with empirical data. Several prominent models, however, predict more than one allometric relationship, and comparisons among alternative models have not taken this into account. Here we evaluate several different scaling models of plant morpholog...

Investigations in the past two decades have shown the utility of the Newtonian model of heat loss from homoiotherms which was established in the biological literature by Scholander et al. (1950a, b, c). The stimulative effect of those papers is seen in a proliferation of thermoregulatory studies (for reviews see Bartholomew, 1968; Dawson & Hudson, 1970). Sufficient data'have been generated from...

In the exercise sciences, simple allometry (y = axb) is rapidly becoming the method of choice for scaling physiological and human performance data for differences in body size. The purpose of this study is to detail the specific regression diagnostics required to validate such models. The sum (T, in kg) of the "snatch" and "clean-and-jerk" lifts of the medalists from the 1995 Men's and Women's ...

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated wit...