or returned to the circulation (as in UO-reinf rats), exert a diuretic effect. In additional experiments, UO rats infused with urea exhibited post-obstructive diuresis, if extracellular volume contraction was prevented. This result suggests that urea may be an important diuretic factor in post-obstructive diuresis, but does not exclude possible roles for other humoral factors. The intact kidney...

Bicarbonate reabsorption in the thick ascending limb of Henle's loop was examined by studies of free-water clearance (CH2O) and free-water reabsorption (TcH2O). During maximal water diuresis in the dog, CH2O/GFR was taken as an indes of sodium reabsorption in, and urine flow (V/GFR) as an index of delivery of filtrate to, this scarbonate, infusion of a nonreabsorbable solute (hypotonic mannitol...

Free water reabsorption (T(c) (H2O)) measured during 10% mannitol diuresis and subsequently during 3% saline diuresis was compared in patients with sickle cell anemia and in normal subjects. During mannitol infusion, T(c) (H2O) progressively rose with increasing osmolar clearance (C(osm)) and reached a maximal level in both groups studied. During hypertonic saline diuresis, T(c) (H2O) progressi...

• In experiments undertaken to produce acute hypertension by left stellate ganglion stimulation, it was observed that during such stimulation a diuresis occurred which was not related to changes in mean arterial pressure. In fact, diuresis was sometimes observed in animals in which mean arterial pressure remained the same or declined. During the diuresis, a decline in left atrial pressure was a...

AB STRA CT In order to assess the renal tubular site(s) at which sodium reabsorption is enhanced in chronic sodium-depletion, seven normal dogs, six saltdepleted dogs, and three normal dogs receiving aldosterone were studied during a steady-state water diuresis under Pentothal anesthesia and during progressive hypotonic saline diuresis. For both maintenance of the water diuresis and progressive...

Acute administration of lithium chloride (Li) to hydropenic anesthetized dogs significantly increased mean arterial pressure (MAP), plasma renin activity (PRA), and urinary prostaglandin E (UPGE) excretion with an increase in urinary volume, osmolar clearance, and sodium excretion. Solute-free water reabsorption increased during Li administration which argues against antagonism to ADH induced b...

It is well established that renal acid excretion can be influenced by certain tubular mechanisms that operate independently of systemic acid-base equilibrium. Thus, the stimulus for sodium reabsorption (1, 2), the competition between potassium and hydrogen ions for secretion (3), and the penetrating ability of anions present in the glomerular filtrate (4-6) are factors known to affect acid excr...

BACKGROUND The purpose of presenting this case is to demonstrate the degree to which the kidney is capable of selectively excreting a massive load of sodium and water when challenged with both of these, without altering the plasma levels of other ions. CASE REPORT An 8-year-old boy was admitted in severe renal failure. Workup demonstrated a high grade obstruction of a single kidney. Following d...

To study the role of circulating natriuretic factors in the postobstructive diuresis that occurs after relief of bilateral, but not unilateral ureteral ligation, cross-circulation was carried out between normal recipient rats and donor rats have either 24-h bilateral (BUL) or unilateral (UUL) ureteral ligation. With BUL donors, there was a rapid marked increase in sodium and water excretion in ...