We report the fabrication of a novel type of artificial small diameter blood vessels, termed biomimetic tissue-engineered blood vessels (bTEBV), with a modular composition. They are composed of a hydrogel scaffold consisting of two negatively charged natural polymers, alginate and a modified chitosan, N,O-carboxymethyl chitosan (N,O-CMC). Into this biologically inert scaffold two biofunctionall...

Cellulose nanocrystals (CNC) were prepared by formic acid hydrolysis and TEMPO- (2,2,6,6-tetramethyl-piperidine-1-oxyl-) mediated oxidation. The CNCs reinforced into biopolymers chitosan (CHI), alginate (ALG), gelatin (GEL) to obtain “CNC-ALG-GEL” “CNC-CHI-GEL” hydrogels. synthesized hydrogels characterized for physicochemical, thermal, structural characterization using Fourier transform infrar...

In the current study, a novel method to improve nano-entrapment of enzymes into Ca-alginate gel was investigated determine synergistic effects ultrasound combined with microwave shock (UMS). The UMS treatment on dextranase enzymes’ loading effectiveness (LE) and immobilization yield (IY) were investigated. By using FT-IR spectra SEM, microstructure immobilized enzyme (IE) characterized. Additio...

background and objective: the opportunistic pathogen pseudomonas aeruginosa secrets a capsule-like polysaccharide called alginate which is important for evasion of host defenses, especially in patients with suppressed immunity. method of alginate determination has an important role in the study of microbial alginate. in this study, a novel method for alginate determination by highperformance li...

Material biopolimer tunggal seperti alginat dan karagenan tidak memiliki sifat fisiko-kimia mekanik yang mencukupi untuk digunakan sebagai produk spesifik bioplastik, sehingga diperlukan kombinasi agar diperoleh hidrogel lebih kuat tahan air. Ion Ca2+ berperan crosslinker polimer bermuatan negative (alginat karagenan) serta meningkatkan struktur jaringan, reologi hidrofobisitasnya, dengan cara ...

Here we describe a novel bioinspired hydrogel material that can be hardened with calcium ions to yield a scaffold material with viscoelastic properties matching those of cartilage. This material consists of a negatively charged biopolymer triplet, composed of morphogenetically active natural inorganic polyphosphate (polyP), along with the likewise biocompatible natural polymers N,O-carboxymethy...

Injection of Algisyl-LVR, a treatment under clinical development, is intended to treat patients with dilated cardiomyopathy. This treatment was recently used for the first time in patients who had symptomatic heart failure. In all patients, cardiac function of the left ventricle (LV) improved significantly, as manifested by consistent reduction of the LV volume and wall stress. Here we describe...

The incorporation of brown algae into biopolymer beads or foams for metal sorption has been previously reported. However, the direct use of these biomasses for preparing foams is a new approach. In this study, two kinds of porous foams were prepared by ionotropic gelation using algal biomass (AB, Laminaria digitata) or alginate (as the reference) and applied for Pb(II) sorption. These foams (ma...

Biopolymer nanoparticles can be formed by heating globular protein/polysaccharide mixtures above the thermal denaturation temperature of the protein under pH conditions where the two biopolymers are weakly electrically attracted to each other. In this study, the influence of polysaccharide linear charge density on the formation and properties of these biopolymer nanoparticles was examined. Mixe...