نتایج جستجو برای: alfa

تعداد نتایج: 18590  

2013
Maissa El Raziky Waleed Fouad Fathalah Wafaa Ahmed El-akel Ahmed Salama Gamal Esmat Mahassen Mabrouk Rabab Mamoun Salama Hany Mahmoud Khatab

BACKGROUND Egypt has one of the highest (16-8%) prevalence rates of HCV infection in the world. Approximately 90% of Egyptian HCV isolates belong to a single subtype (4a), which responds less successfully to interferon therapy than other subtypes. Studies comparing the efficacy and safety of PEGIFN alfa-2a and PEGIFN alfa-2b in treatment-naive HCV-infected patients have shown conflicting result...

Journal: :Archives of general psychiatry 2012
Lucile Capuron Giuseppe Pagnoni Daniel F Drake Bobbi J Woolwine James R Spivey Ronald J Crowe John R Votaw Mark M Goodman Andrew H Miller

CONTEXT Inflammatory cytokines or cytokine inducers can alter basal ganglia activity, including reducing responsiveness to rewarding stimuli that may be mediated by cytokine effects on dopamine function. OBJECTIVES To determine whether long-term administration of the inflammatory cytokine interferon alfa reduces the basal ganglia response to reward and whether such changes are associated with...

Journal: :Gut 1993
N C Tassopoulos M G Koutelou G Papatheodoridis H Polychronaki I Delladetsima T Giannikakis A Todoulos A Toliopoulos A Hatzakis

To assess the safety and possible efficacy of recombinant human interferon alfa-2b in preventing the development of chronic hepatitis, 24 adults (eight men, 16 women) with acute non-A, non-B (NANB) hepatitis were recruited to a pilot study. Half of the cases were parenterally transmitted and half were community acquired. Twelve patients received 3 million units (MU) interferon three times weekl...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2008
Tracy McGowan Nicole M Vaccaro Jessica S Beaver Joseph Massarella Marsha Wolfson

BACKGROUND AND OBJECTIVES Emerging evidence suggests that epoetin alfa can be administered at extended intervals of up to 4 wk. This open-label, randomized study was performed to characterize the pharmacokinetic and pharmacodynamic profiles of four dosing regimens of epoetin alfa administered subcutaneously in anemic patients who had chronic kidney disease and were not on dialysis. DESIGN, SE...

2016
Gregory M. Pastores Suma P. Shankar Milan Petakov Pilar Giraldo Hanna Rosenbaum Dominick J. Amato Jeffrey Szer Raul Chertkoff Einat Brill‐Almon Ari Zimran

Taliglucerase alfa is the first available plant cell-expressed human recombinant therapeutic protein. It is indicated for treatment of patients with type 1 Gaucher disease (GD) in adult and pediatric patients in several countries. Study PB-06-002 examined the safety and efficacy of taliglucerase alfa for 9 months in patients who previously received imiglucerase. The results of adult patients fr...

Journal: :Pediatrics 2005
Dominic A Fitzgerald Jodi Hilton Beverly Jepson Lucia Smith

OBJECTIVE Although dornase alfa is a widely used, aerosolized, mucolytic agent in patients with cystic fibrosis (CF), its efficacy in relation to the timing of physiotherapy has not been tested. We sought to determine whether dornase alfa is more efficacious when it is administered 30 minutes before versus 30 minutes after physiotherapy/positive expiratory pressure (PEP) therapy in clinically s...

2015
Jacques Friborg Petra Ross-Macdonald Jian Cao Ryan Willard Baiqing Lin Betsy Eggers Fiona McPhee

Peginterferon lambda-1a (Lambda), a type III interferon (IFN), acts through a unique receptor complex with limited cellular expression outside the liver which may result in a differentiated tolerability profile compared to peginterferon alfa (alfa). In Phase 2b clinical studies, Lambda administered in combination with ribavirin (RBV) was efficacious in patients with hepatitis C virus (HCV) infe...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006
John Hornberger Francesca J Torriani Douglas T Dieterich Norbert Bräu Mark S Sulkowski Maribel Rodriguez Torres Jesse Green Kavita Patel

BACKGROUND A multinational trial (APRICOT) showed that peginterferon alfa-2a (40kDa) plus ribavirin is efficacious for treatment of HIV-HCV co-infection. The cost-effectiveness of treating these patients with peginterferon alfa-2a/ribavirin has yet to be explored from a US societal perspective. OBJECTIVE To predict the cost-effectiveness of peginterferon alfa-2a/ribavirin with interferon/riba...

2010
Boris Brumshtein Paul Salinas Brian Peterson Victor Chan Israel Silman Joel L Sussman Philip J Savickas Gregory S Robinson Anthony H Futerman

Gaucher disease, the most common lysosomal storage disease, can be treated with enzyme replacement therapy (ERT), in which defective acid-beta-glucosidase (GlcCerase) is supplemented by a recombinant, active enzyme. The X-ray structures of recombinant GlcCerase produced in Chinese hamster ovary cells (imiglucerase, Cerezyme) and in transgenic carrot cells (prGCD) have been previously solved. We...

2017
Wolfgang Koechling Daniel Plaksin Glenn E Croston Janni V Jeppesen Kirsten T Macklon Claus Yding Andersen

Recombinant FSH proteins are important therapeutic agents for the treatment of infertility, including follitropin alfa expressed in Chinese Hamster Ovary (CHO) cells and, more recently, follitropin delta expressed in the human cell line PER.C6. These recombinant FSH proteins have distinct glycosylation, and have distinct pharmacokinetic and pharmacodynamic profiles in women. Comparative experim...

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