Molybdenum (Mo) is a trace dietary element that essential for human survival. Several molybdenum-containing enzymes (e.g., aldehyde oxidase, xanthine oxidase and sulfite oxidase) are associated with key metabolic activities in the body. Molybdenum-based nanomaterials (Mo-NMs), including molybdenum dichalcogenides, oxides, molybdenum-based polyoxometalates, nanocomposites, have been extensively ...

A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (approximately 3-fold) ...

Formaldehyde was shown to be a normal metabolite when Handler, Bernheim, and Klein (1) found sarcosine oxidase which catalyzes the oxidative demethylation of sarcosine to glycine and formaldehyde. Sakami (2), Welsh and Sakami (3), and Stekol et al. (4) have recently presented evidence that formate may provide the animal with necessary methyl groups. It was therefore of interest to investigate t...

Formaldehyde was shown to be a normal metabolite when Handler, Bernheim, and Klein (1) found sarcosine oxidase which catalyzes the oxidative demethylation of sarcosine to glycine and formaldehyde. Sakami (2), Welsh and Sakami (3), and Stekol et al. (4) have recently presented evidence that formate may provide the animal with necessary methyl groups. It was therefore of interest to investigate t...