Abstract Background Alcohol-related liver disease (ALD) is a major cause of chronic diseases. Inflammatory response basic pathological feature ALD. Mucosal-associated invariant T(MAIT) cells are novel population innate immune cells, which may be depleted in various inflammatory However, the changes MAIT cell ALD remains unclear. Results In this study, levels were significantly decreased patient...

Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD). Furthermore, a crosstalk between vitamin D and bile acid synthesis has recently been discovered. Whether this crosstalk has an influence on the course of...

Globally, an estimated one million deaths occur annually due to complications of cirrhosis. Cirrhosis with end stage liver disease [ESLD] is a leading cause death noncommunicable diseases in Sri Lanka. Non-alcoholic fatty [NAFLD] and alcohol related [ARLD] are the principal causes ESLD cirrhosis Liver transplantation remains only curative treatment for such patients. Multiorgan dysfunction hemo...

We present a rare case of long-term alcoholic liver disease that progressed from alcoholic liver fibrosis to alcoholic liver cirrhosis, and following passive abstinence, the patient's condition then improved to alcoholic liver fibrosis. A 70-year-old Japanese man who had consumed large amounts of alcohol since he was 20 years old received a liver biopsy for evaluation of liver dysfunction at th...

Background The rate of hospital admissions for cirrhosis increased 1.3-fold during 2008–2016 in Queensland. Alcohol misuse was a contributing factor 55% and 40% patients had at least one comorbidity. Aims To examine the temporal change aetiology liver disease presence comorbidity admitted with cirrhosis. Methods Population-based retrospective cohort study all people treated (10 254 patients) Qu...

BACKGROUND Although most epidemiological studies do not support a role for alcohol in the aetiology of pancreatic cancer, an increased risk among heavy drinkers cannot be excluded. METHODS In a retrospective cohort based on the Swedish Inpatient Register, we analysed the risk of pancreatic cancer among patients admitted to hospital for alcoholism (n=178 688), alcoholic chronic pancreatitis (n...

Alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) and cytochrome P-4502E1 (CYP2E1), and then to acetate by aldehyde dehydrogenase (ALDH). Polymorphisms of these ethanol-metabolizing enzymes may be associated with inter-individual difference in alcohol metabolism and susceptibility to alcoholic liver disease. We determined genotype and allele frequencies of ALDH2, CYP2E1, ADH2, ...

Background: Although most epidemiological studies do not support a role for alcohol in the aetiology of pancreatic cancer, an increased risk among heavy drinkers cannot be excluded. Methods: In a retrospective cohort based on the Swedish Inpatient Register, we analysed the risk of pancreatic cancer among patients admitted to hospital for alcoholism (n=178 688), alcoholic chronic pancreatitis (n...

The different sensitivity of the male and the female liver is well established, but there is an obvious difference in male livers as well. One possible explanation for these differences might be the existence of genetic peculiarities among patients with alcoholic cirrhosis. In the early twentieth, Chvostek in Vienna was the first to draw attention to a constitutional element which he believed t...

Alcoholic liver disease (ALD) is a spectrum ranging from simple hepatic steatosis to alcoholic hepatitis and cirrhosis. Patients with severe alcoholic hepatitis can have clinical presentation almost similar to those with decompensated cirrhosis. Scoring with models like Maddrey discriminant function, a model for end-stage liver disease, Glasgow alcoholic hepatitis score, and Lille model are hel...