BACKGROUND Ras signalling is frequently aberrant in pancreatic cancer so that there is constitutive activation of the phosphatidylinositol 3-kinase (PI3K) and AKT/protein kinase B pathway, as well as the RAF/MEK/ERK pathway. AIMS In the present study we investigated the role of the PI3K/AKT pathway in malignant transformation of pancreatic cancer cells. METHODS A genetic approach was used t...

The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied independently. Here, we asked whether the Akt pathway regulates the UPR. To this end, we used a series of chemical compounds that modulate PI3K/Akt pathway and monitored th...

Pancreatic ductal adenocarcinoma (PDAC) is a growing cause of cancer-related mortality worldwide. Kallikrein-related peptidase 8 (KLK8) has potential clinical values in many cancers. However, the clinicopathological significances KLK8 PDAC remain unknown. We explored relationship to features based on public databases. expression was examined human tissues. Cell proliferation and apoptosis were ...

Cholangiocarcinoma (CCA) is a highly aggressive form of liver cancer, but its pathogenesis far from being fully elucidated. Recent studies have reported that Serine/threonine kinase 39 (STK39) overexpressed in various tumor tissues and plays an essential role progression. However, the STK39 CCA still unclear. In this study, we investigated clinical value as well potential functions mechanisms C...

Background: Ras signalling is frequently aberrant in pancreatic cancer so that there is constitutive activation of the phosphatidylinositol 3-kinase (PI3K) and AKT/protein kinase B pathway, as well as the RAF/MEK/ERK pathway. Aims: In the present study we investigated the role of the PI3K/AKT pathway in malignant transformation of pancreatic cancer cells. Methods: A genetic approach was used to...

Prostate cancer (PC) is one of the prevalent tumors in men causing higher mortality. Luteoloside has been discovered for suppressive role into progression some cancers. However, Luteoloside’s regulatory functions regarding PC are not well understood. This study thus designed to investigate impact on progression. In this work, it was demonstrated that cell proliferation gradually inhibited with ...

Traditional Chinese medicine (TCM) had demonstrated effectiveness in the prevention and control of COVID-19. Statistics showed that Ephedra Glycyrrhiza were frequently used treatment We hypothesized Ephedra-Glycyrrhiza drug pair is a potential choice for Here, 112 active compounds identified from via network pharmacology approach. enrichment analysis these might participate cAMP, PI3K-Akt, JAK-...

Many host cellular signaling pathways were activated and exploited by virus infection for more efficient replication. The PI3K/Akt pathway has recently attracted considerable interest due to its role in regulating virus replication. This study demonstrated for the first time that the mammalian reovirus strains Masked Palm Civet/China/2004 (MPC/04) and Bat/China/2003 (B/03) can induce transient ...

The phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway has attracted much recent interest due to its central role in modulating diverse downstream signalling pathways associated with cell survival, proliferation, differentiation, morphology and apoptosis. An increasing amount of information has demonstrated that many viruses activate the PI3K/Akt pathway to augment their efficient repl...

Introduction Resveratrol, a polyphenol extracted from many plant species, has emerged as promising pro-apoptotic agent in various cancer cells. However, the role of resveratrol cell proliferation and apoptosis fibroblast-like synoviocytes rheumatoid arthritis (RA-FLS) is not fully understood. The study was aimed at elucidating RA-FLS underlying molecular mechanism. Material methods Cultured RA-...