•Genetic analysis was performed on 7,970 individuals hospitalized for COVID-19•Five SNPs within TMPRSS2/MX1 locus (chr.21) are associated with severe COVID-19•The minor alleles of the five correlated high level MX1 expression in blood•MX1 could be a potential therapeutic target patients COVID-19 The established risk factors coronavirus disease 2019 (COVID-19) advanced age, male sex, and comorbi...

Perceptual stability is ubiquitous in our everyday lives. Objects in the world may look somewhat different as the perceiver’s viewpoint changes, but it is rare that their essential stability is lost and qualitatively different objects are perceived. In this chapter we examine the source of this stability based on the principle that perceptual experience is embodied in the neural activation of e...

Photo by Marek Studzinski on Unsplash ABSTRACT Payment models directly impact the way patients experience care. Historically, payment model innovations have been examined mostly from economic, organizational, and public health lenses. Financial incentives exist in all healthcare systems, whether a socialized, private or insurance, single payer system. This article examines alignment of current ...

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth survival, many which are independent classical cellular bioenergetics. These include modulation ferroptotic-mediated support during metastasis, interactions with...