In a phase II trial, the tyrosine kinase inhibitor sunitinib was effective in previously treated patients with thymic carcinoma, offering the first viable second-line treatment option for patients with this rare and aggressive form of thymus cancer.

Aggressive angiomyxoma is a rare soft-tissue tumor which usually occurs in female patients of reproductive age. Its occurrence in men is even more unusual and as illustrated in this case the difference between pathology suggested by a physical examination and its actual extent can be quite striking. We present a case report of an 81-year-old man with the typical MRI appearances of a pelvic aggr...

This study explores the social impact of ADHD, with and without opposition-defiant behaviour (ADHD+ODD (n= 22) and ADHD-only (n= 18)), in 9- to 12- year old girls compared to girls without ADHD (n= 40). Girls played a computer game involving simulated players, and mothers and teachers completed rating scales. In general, mothers and teachers saw girls with ADHD+ODD as more overtly and relationa...

Solid-phase radioimmunoassay (SPRIA) techniques have been valuable for quantifying antibody to bacteria (I) and viruses (2,3). In the indirect solid-phase radioimmunoassay technique, a purified antigen is usually attached directly to the solid phase. The attached antigen is then exposed to the human test serum; and after thorough washing, antibodies combined with the antigen are detected by mea...

Aggressive angiomyxoma is a rare mesenchymal tumour predominantly affecting the female pelvis and perineum but has also been described in males. This tumour can often present a diagnostic challenge and has a propensity for local recurrence after surgical excision. We present an unusual case of aggressive angiomyxoma arising from the bladder of a female patient which required local excision and ...

Despite frequent suggestions that dominance-subordination relationships in infancy can affect subsequent agonistic potential during adult life, to our knowledge no explicit test has been made. Experiments have shown that adverse conditions during early development can have long-term effects on a variety of traits ranging from growth to competitive behaviour. In many vertebrate species, the main...

introduction: giant cell lesions of the bone comprise a group of jaw bone pathologies. different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. in addition, differentiating between aggressive and nonaggressive central giant cell granuloma (cgcg) of the jaws based on histopathologic features is still impossible and due to different treatment protocols...

dental implants have provided exceptional rehabilitative options for edentulous and partially edentulous patients. however, as more implants come into play, the more the clinicians come across problems where specific considerations must be taken into account to meet expectations. the toronto bridge is a treatment modality proposed for restoring several teeth lost in patients with increased crow...

background: there is a strong evidence that genetic as well as environmental factors affect the age of onset, severity and lifetime risk of developing periodontitis. the objective of the present study was to compare and to evaluate the association between interleukin (il)-1α(-889) and gene polymorphisms in patients with generalized aggressive periodontitis, chronic periodontitis and healthy con...