Elongated mesenchymal migration of cancer cells is driven by Rac1 activation mediated by the adaptor NEDD9 and the exchange factor DOCK3. A new study reports a role for the transcription factor Twist1 in inducing mesenchymal migration by relieving the suppression of NEDD9 and DOCK3 by the microRNA let-7i.

Background Sitting posture is a common aggravating factor for pain both at the cervical and lumbar spine regions, with extended periods of sitting associated with increased discomfort at the neck and upper and lower back. Sitting postures independently adopted by asymptomatic individuals in comparison to theorized ‘optimal’ sitting postures have not been fully evaluated (O’Sullivan et al., 2010...

A 30-year-old woman presented at our family planning clinic for Implanon removal and reinsertion. At the time of presentation the patient's weight was 148 kg. The Implanon was fitted in July 2000 (i.e. 35 months previously) when her weight was 138.5 kg. The patient was very happy with the contraceptive method. She was aware that her Implanon had snapped in half about 2 months ago. There was no ...