Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA). Materials and Methods: Male adult mice were divided into four treatment...

Background: The concepts of reproductive biology were changed by stating the ovarian reserve in postnatal mammalian females is replenished. The aim of this study was to investigate the expression of OCT4 in the mice ovarian tissue during different stages of mouse estrous cycle. Materials and Methods: The mice were considered as pro-estrous, estrous, met-estrous and di-estrous based on the cell ...

A diet containing adequate amounts of protein rapidly suppresses myofibrillar protein degradation after refeeding in young rats and mice. However, it is unclear whether this suppression is seen in adult animals. This study was undertaken to compare dietary protein-induced suppression of myofibrillar protein degradation in young and adult mice. Reductions in rates of myofibrillar protein degrada...

Background: The present study was carried out to investigate the possible protective effects of royal jelly (RJ) on oxymetholone (OXM)-induced oxidative liver injuries in mice. Methods: In total, 32 adult male NMRI mice were divided into four groups of eight mice each. Mice in groups 1 and 2 were orally administered 5 mg/kg/day OXM for 30 days. At the same time, mice in group 3 received RJ at a...

The transplantation of adipose-derived multipotent mesenchymal stromal cells (ADSCs) in Parkinson’s disease/parkinsonism is a promising area their therapy. effects such may be influenced by the age donor and biologically active factors. purpose study to compare effect transplanted ADSCs mice different on parameters behaviour, oxidative stress neuroinflammation brain with an experimental model p...

The aim of this study, evaluate the nociceptive effect adalimumab, a TNF-alpha inhibitor, on formalin-induced inflammatory pain in mice. antinociceptive activity adalimumab was determined adult male BALB-C mice (6 each group) by model and hot plate test applied. Diclofenac, which we used as positive control, showed anti-nociceptive both phases formalin test. at thirtieth minute statistically si...

objective: this study aimed to investigate the effects of royal jelly (rj) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (oxm). materials and methods: in this exprimental study, 32 male and 96 female adult naval medical research institute (nmri) mice (7-9 weeks of age) with a ratio of 1:3 for fertilization purposes were randomly divided i...

Background: It is assumed that adult stem/progenitor cells are responsible for cycling remodeling of the uterus endometrium throughout the reproductive life of the female. This study aimed to identify and localize stem/progenitor cells in the mice uterus using immunohistochemistry. Materials and Methods: 6-8 weeks old virgin female NMRI mice were submitted to the vaginal smear examination to de...

Background Pyrethroids are commonly used as insecticides for both household and agricultural applications, and have recently been linked to endocrine disruption. Cypermethrin is a type П pyrethroid which is used widely throughout the world. The present study was aimed to investigate the effects of cypermethrin on the sexual behaviour and plasma level of pituitary-gonadal hormones of adult male ...

Adult mice are more resistant than neonatal mice to intestinal colonization with the protozoan parasite Cryptosporidium parvum. Development of a mature intestinal flora may play a role in this resistance. We compared susceptibilities to colonization with C. parvum in adult conventional mice, adult germfree mice, and adult conventional mice treated with oral antibiotics to deplete the intestinal...