Primary aldosteronism is a potentially curable cause of hypertension, especially when caused by an adrenal adenoma. Aldosteronomas because of their small size often elude techniques to locate them. This case illustrates the advantages, disadvantages and complications of noninvasive techniques used for their diagnosis. A patient with hypertension and hypokalemia underwent an adrenal venous efflu...

Introduction: Pheochromocytomas are catecholamine-producing neuroendocrine tumors that arise from the adrenal medulla. typically present with uncontrollable or paroxysmal hypertension can be accompanied by other common initial symptoms, including headache, diaphoresis, arrhythmia, and pallor. Given morbidity mortality associated undiagnosed pheochromocytomas, their potential for treatment, prim...

BACKGROUND Adrenal pseudocysts are often discovered incidentally on imaging, but the diagnosis and treatment can be challenging. A case of adrenal pseudocyst with hemorrhage is presented that mimicked a solid tumor on imaging, resulting in adrenalectomy. CASE REPORT A 78-year-old woman was found to have a right adrenal lesion on abdominal imaging. Enhanced computed tomography (CT) showed a hete...

A rare case of exophytic hepatic hemangioma preoperatively diagnosed as a non-functioning adrenal tumor is reported. A 62-year-old man was admitted for treatment of primary hyper-parathyroidism and an incidental adrenal tumor. A 4.0 x 2.5 cm heterogeneous tumor located between the liver and the right kidney was detected by abdominal ultrasonography, computed tomography and magnetic resonance im...

Primary adrenal leiomyosarcoma is extremely rare tumor. We report a case with adrenal leiomyosarcoma. Our case was a 48-year-old man who presented with lower urinary tract symptoms. Ultrasonography and magnetic resonance imaging revealed approximately 9 cm solid mass originating from right adrenal gland. He underwent right adrenalectomy. Pathology of the specimen showed histologic and immunohis...

CONTEXT In male patients with congenital adrenal hyperplasia (CAH), testicular adrenal rest tumors are frequently found that may interfere with gonadal function. OBJECTIVE Our objective was to determine steroid-producing features of testicular adrenal rest tumors. DESIGN AND SETTING The study is descriptive and took place at a university medical center. PATIENTS Eight adult CAH patients w...

As has been reported previously by Diller and Shear (6) and by Diller (4), tumor cells of mice injected with a polysaccharide derived by Shear (9) from Serratia marcescens culture filtrate show degenerative responses within 6 hours. At a dose level that produced rapid sloughing of sarcoma 37 in about 1 out of every 4 mice, an equal number of mice usually succumbed to treatment. When adrenal cor...

Li–Fraumeni syndrome (LFS) is an autosomal dominant hereditary cancer associated with germline pathogenic variants in the tumor protein p53 (TP53) gene and elevated risk of a broad range early-onset malignancies. Patients LFS are at second third primary tumor. A 15-month-old girl consulted for clitoromegaly pubic hair. Adrenal ultrasound detected large left adrenal Left total adrenalectomy conf...

OBJECTIVE To recognize that benign adrenal adenomas can co-secrete excess aldosterone and cortisol, which can change clinical management. METHODS We reviewed the clinical and histological features of an adrenal tumor co-secreting aldosterone and cortisol in a patient. Biochemical testing as well as postoperative immunohistochemistry was carried out on tissue samples for assessing enzymes invo...

We constructed a human pheochromocytoma cDNA library and used differential hybridization to human pheochromocytoma and human neuroblastoma cDNA probes to isolate genes that are highly expressed in the adrenal medullary neuroendocrine tumor, pheochromocytoma, but not in the more immature embryonal tumor of adrenal medulla, neuroblastoma. Two cDNA clones, pG8 and pG2, were more highly expressed i...