Urocortin (UCN) 1, 2, and 3 are members of the corticotropin-releasing factor (CRF) family that display varying affinities to the CRF receptor 1 (CRFR1 (CRHR1)) and 2 (CRFR2 (CRHR2)). UCNs represent important modulators of stress responses and are involved in the control of anxiety and related disorders. In addition to the CNS, UCNs and CRFRs are highly expressed in several tissues including th...

introduction the dexamethasone test has been widely used for diagnosing hypercortisolism. materials and methods we assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved cushing&apos;s disease. results a statistically highly significant correlation was found (for urine cortisol: r = 0.66, p <0.0...

The adrenal gland has characteristic morphological and biochemical features that render it particularly susceptible to the actions of xenobiotics. As is the case with other endocrine organs, the adrenal gland is under the control of upstream organs (hypothalamic-pituitary system) in vivo, often making it difficult to elucidate the mode of toxicity of a test article. It is very important, especi...

The Indian sheath-tailed bat, Taphozous longimanus at Nagpur (Maharashtra State) shows continuous asynchronous breeding, exhibiting aseasonal polyoestry. The adrenal gland of Taphozous is made up of the steroidogenic and chromaffin cells. The ultrastructural features of the glomerulosa cells during estrus are inconspicuous Golgi complex mitochondria with vesicular cristae, a few lipid droplets ...

primary adrenal lymphoma is extremely rare. we report a case with primary bilateral adrenal lym-phoma in a young male patient. he presented with abdominal pain and weight loss. pathologic study revealed malignant lymphoma, diffuse large cell type (t- cell origin). patient recieved combination chemotherapy and radiation therapy but 22 months after diagnosis died because of progression of dis ease

pheochromocytoma is a catecholamine‑producing tumor. there are a very few reported cases of clinical pheochromocytoma. here, we report a 27‑year‑old woman para 1 live 1 with chief complaint of headache, confusion, nausea, and vomiting 2 days after cesarean section. she was anxious and had palpitation. on physical examination, fever, tachycardia, tachypnea, high blood pressure, and right thyroid...

Among extrahepatic tissues the adrenal gland has one of the highest concentrations of apoE mRNA and the highest rate of apoE synthesis. In the present investigation several previously described in vivo treatments were used to assess the relationship between apoE expression and cellular cholesterol in the rat adrenal gland. Treatment of rats with 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) to lower...

Because of the time factor involved, it would be an impossible task to present the vast body of biochemical information accumulated during the last decade on the endocrine aspects of pregnancy. However, certain key points can be made concerning the feto-placental unit and the hormone levels and effects in normal gestation. These concepts will be discussed not merely for their academic value, bu...

It has been shown earlier (1) that the metabolism of carbohydrate is disturbed in scorbutic guinea pigs as evidenced by diminished glucose tolerance, deposition of liver glycogen, and insulin content of the pancreas. Although the adrenalin content of the adrenals of scorbutic guinea pigs is increased, it has been shown by removing the adrenal medulla that adrenalin is not responsible for the lo...

The surgery of the adrenal gland is a subject which is expanding rapidly at the present time. Kendall's work on the identification of adrenal cortical hormones, leading in recent years to a plentiful supply of cortisone, has made such operations relatively safe. In addition, increased knowledge about the physiology of the gland has put this branch of surgery on a more rational basis. This artic...