In this study, we developed a mouse model of adoptive immunotherapy reflecting immune recognition of syngeneic tumor cells naturally expressing an endogenous rejection Ag. Specifically, in a pulmonary metastases model, we examined the potency and maintenance of an antitumor CD8(+) CTL response in vivo, as well as its effectiveness against an "extensive" tumor burden. The approach taken was to f...

Macrophages are less effective than DC at priming naive CD4(+) T cells, suggesting that DC are unique in initiating T cell-dependent Ab responses. We compared the ability of DC and macrophages, pulsed in vitro with Streptococcus pneumoniae, to elicit protein- and polysaccharide-specific Ig isotype production upon adoptive transfer into naive mice. S. pneumoniae-activated DC secreted more proinf...

In this study, we used an adoptive lymphocyte transfer experiment to evaluate the ability of the P64k recombinant protein to recruit T-helper activity and induce immunologic memory response to the polysaccharide moiety in a meningococcal serogroup C conjugate vaccine. Adoptive transfer of splenocytes from mice immunized with the glycoconjugate conferred antipolysaccharide immunologic memory to ...

control of well drilling operations poses a challenging issue to be tackled. the loss of well control could lead to the occurrence of blowout as a severe threat, involving the risk of human lives and environmental and economic consequences. conventional proportional-integral (pi) controller is a common practice in the well control operation. the small existing margin between pore pressure and f...

Vaccination suppresses Helicobacter pylori colonization but does not cure infection. Furthermore, postvaccination gastritis, likely induced by enhanced host response to residual colonization, may exacerbate disease. The goal of this study was to determine if adoptive transfer of C57BL/6 splenocytes to C57BL/6scid/scid (severe combined immunodeficient [SCID]) mice cures infection without exacerb...

Session 1. Mutated tumor antigens and adoptive cell therapy in the clinics Chair: Per Thor Straten (Copenhagen) and Giorgio Parmiani (Milan/Siena) 14.15 Paul Robbins (Bethesda): Targeting mutated antigens by adoptive cell therapy. 14:40 Anna Mondino (Milan): Novel strategies to improve adoptive T cell therapy for solid tumors 15:05 Per Thor Straten (Copenhagen): Cancer therapy using tumor infil...

Objective: To examine how lesbian, gay, and heterosexual adoptive parents navigate openness dynamics with children’s birth family across a 5-year period, when children are preschoolto school-age. Background: Few studies regarding birth family contact have included longitudinal data as well as a sample of adoptive parents of varying sexual orientations. Thus, this study used a multiprong theoret...