Purpose The panel updated the American Society of Clinical Oncology (ASCO) adjuvant therapy guideline for resected non-small-cell lung cancers. Methods ASCO convened an update panel and conducted a systematic review of the literature, investigating adjuvant therapy in resected non-small-cell lung cancers. Results The updated evidence base covered questions related to adjuvant systemic therapy a...

Approximately one-third of patients with epithelial ovarian cancer present with localized disease confined to the ovaries or pelvis (International Federation of Gynecology and Obstetrics [FIGO] stages I and II). Although their long-term prognosis is better (10-year survival 50%–70%) than that of patients with advanced ovarian cancer (10-year survival 15%–25%), approximately 50% of women with ea...

The incidence of advanced stage colorectal cancer (CRC) patients is increasing. Adjuvant chemotherapy [5-fluorouracil/leucovorin plus oxaliplatin (FOLOX) or capecitabine plus oxaliplatin (XELOX) is the standard treatment for patients with stage III CRC following surgery, with the objective of avoiding tumor recurrence and metastasis. However, the selection of an optimal treatment regimen is sti...

We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the in...

Purpose. The purpose of this study was to analyse the height at diagnosis and growth in 72 skeletally immature children who had been treated for osteosarcoma in the area of the knee.Subjects. Of the patients, the average age at diagnosis was 10 years in girls and 12 years in boys. All children received neo-adjuvant chemotherapy, and had limb salvage by endoprosthetic replacement.Results and con...

BACKGROUND The aim of this study was to determine the evolution in treatment recommendations and outcomes for patients with subcentimeter, node-negative, triple-negative disease. METHODS Patients were divided into a remote (diagnosed from 1997 to 2003) and a recent (diagnosed from 2004 to 2011) group. Demographics, tumor size, surgical treatment, use of adjuvant chemotherapy, survival, and di...

patients with malignancy are at higher risk of thrombotic complications due to the hypercoagulability state. our objective in this study was to assess the serum concentrations of homocysteine, anti phospholipid antibodies, and anti cardiolipin in patients with benign and malignant breast tumors and study the effect of chemotherapy on the serum levels of these markers. a case control study was c...

background : this prospective study assessed the efficacy of neoadjuvant and adjuvant chemotherapy on patients with high risk soft tissue sarcomasof the extremities. methods : enrolled patients received the following neoadjuvant chemotherapy: doxorubicin (75 mg/m2) on day1, ifosfamide (2.5 g/m2/d) and mesna (20% of the ifosfamide dose) from days1 to 3, repeated every three weeks for a total of ...

BACKGROUND Markers of preoperative tumor immunity, such as platelet-to-lymphocyte ratio (PLR), have been reported to be prognostic factors for patients with various cancers. However, the relationship between PLR and the prognosis of non-small cell lung cancer (NSCLC) patients treated with surgery and adjuvant chemotherapy as a multidisciplinary treatment is unknown. METHODS We enrolled 327 NS...

BACKGROUND In patients undergoing surgery for resectable pancreatic cancer prognosis still remains poor. The role of adjuvant treatment strategies (including chemotherapy and chemoradiotherapy) following resection of pancreatic cancer remains controversial. METHODS A Medline-based literature search was undertaken to identify randomized controlled trials that evaluated adjuvant chemotherapy af...