First, we wish to express our great thanks to Prof. Kim for choosing our article and for noting an important point in our study. During the past few years, metabolically healthy obesity (MHO) has been a hot topic of debate in the field of obesity because its definition differs slightly from that of metabolic syndrome and because the inclusion of insulin resistance and systemic inflammatory mark...

Visfatin is an adipocytokine capable of mimicking the glucose-lowering effects of insulin and activating the pro-survival kinases phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (Akt) and mitogen-activated protein kinase kinase 1 and 2 (MEK1/2)-extracellular signal-regulated kinase 1 and 2 (Erk 1/2). Experimental studies have demonstrated that the activation of these kinases confers ca...

BACKGROUND Adipose tissue is a veritable "endocrine organ" due to its adipocytokines secretion implied in insulin sensitivity modulation and cardiovascular complications. OBJECTIVE To identify the adipocytokines' plasmatic profile (adiponectin, leptin, resistin, IL-6, TNFα) in obese children and adolescents and to assess their relationship with "classic" clinical/paraclinical markers of metab...

BACKGROUND Endothelial dysfunction is an independent risk factor for cardiovascular events. Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction. This study addressed the relationship of adipocytokines with endothelial function and blood pressure. METHODS In 92 newly diagnosed, drug-naïve essential hypertensive patients (HT, me...

Obesity is a chronic disease affecting millions of individuals around the world and has taken epidemic proportions. Often, obesity is associated with other risk factors such as hypertension and dyslipidemia, increasing metabolic syndromerelated complications. Such complications include several cancer types, namely breast cancer. Several mechanisms are likely to be involved in cancer development...

Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer's disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system throu...