background: leukemia inhibitory factor (lif) is a neurortophic cytokine which plays an important role in the neural cell survival. expression of lif and its receptor, lifr, in different brain regions has been demonstrated. based on evidences lif plays an important role in the modulation of neurogenesis and glial responses to injury. up-regulation of lif after central nervous system (cns) damage...

objective: this study was to evaluate the effect of vitamin c on the histology and histochemistry of the prefrontal cortex of ethanol-induced rats. methods: male sprague-dawley rats were used for the study. ethical approval was obtained from the university’s ethical committee. the rats were randomly divided into 6 groups of 10 rats each. rats in group a= free access to normal saline. rats in gr...

testosterone enanthate (te) is used by many athletes as a muscle builder. previous studies showed that high concentration of the drug in plasma may affect the natural function of endocrine glands, specially the secretion of the adrenocortical hormones. the objective of the present study was to examine the effects of high concentration of te on histometrical structure of adrenal cortex in male r...

introduction: neurons in layer ii and iii of the somatosensory cortex in rats show high frequency (33 ± 13 hz) of miniature excitatory postsynaptic currents (mepscs) that their rates and amplitudes are independent of sodium channels. there are some changes in these currents in neurodegenerative and psychological disorders. regarding to well known roles of the neuromodulatory brain systems in th...

introduction: electrical low-frequency stimulation (lfs) has antiepileptic effect, but the role of different stimulation parameters on this effect has not been determined. in this study the effect of different lfs parameters (intensity, pulse duration and train duration) on piriform-cortex kindled seizures was investigated. methods: seizure was produced in animals using kindling model of epilep...

Germ-line p53 mutations are associated with dominantly inherited Li-Fraumeni syndrome (LFS), which features early-onset sarcomas of bone and soft tissues, carcinomas of the breast and adrenal cortex, brain tumors, and acute leukemias. However, carriers of germ-line p53 mutations may also be at increased risk of other cancers. To clarify the tumor spectrum associated with inherited p53 mutations...

Neuroimaging research indicates that human intellectual ability is associated to brain structure including the thickness of the cerebral cortex. Most studies show that general intelligence is positively associated with cortical thickness in areas of association cortex allocated throughout both brain hemispheres. Changes in cortical thickness over time have been related to intelligence, but whet...

background: alzheimer’s disease (ad) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. the aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of ad. methods: adult male albino wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. the rats were randomly assigned t...

In infants and children, pancreatic neoplasms occur uncommonly. Histologically, these tumors can resemble pancreatic embryonic elements or more well-differentiated pancreatic structures, in a subset the cellular origin can’t be delineated. This review discusses three of the most classic pediatric pancreatic neoplasms: pancreatoblastoma, solid pseudopapillary neoplasms and pancreatic endocrine n...

Spontaneous tunmrs in the Syrian (golden) hamster most commonly originate in the gastrointestinal tract, adrenogenilal systems, and in reticuloendothelial tissues. Neoplasms of diverse origin were found in 81.9 per cent of 94 control males and 60.9 per cent of 87 control females. Multiple types of tumors originated in a single animal. In the controls, 43.6 per cent of the males and ~0.7 per cen...