The protective roles of Ca channel blockers against ischemic hippocampal damage are still debated. We used autoradiography to study postischemic L-type Ca channels (1,4dihydropyridine Ca channel blocker binding), adenosine A, receptors, and muscarinic chollnergic receptors in the rat hippocampus using [H]PN200-110 (PN), [H]cyclohexyladenosine (CHA), and [H]quinuclidinyl benzilate (QNB), respect...

Adenosine 1 receptors (A1AR) have been shown in previous experiments to play a major role in the tubuloglomerular feedback (TGF) constrictor response of afferent arterioles (AA) to increased loop of Henle flow. Overexpression studies have pointed to a critical role of vascular A1AR, but it has remained unclear whether selective deletion of A1AR from smooth muscle cells is sufficient to abolish ...

Rita Maciel, Raquel Palma, Pedro Sousa, Fátima Ferreira, Hipólito Nzwalo Department of Internal Medicine, Centro Hospitalar do Algarve (CHA), Faro, Portugal Stroke Unit, Centro Hospitalar do Algarve (CHA), Faro, Portugal Department of Neurology, Centro Hospitalar do Algarve (CHA), Faro, Portugal Department of Cardiology, Centro Hospitalar do Algarve (CHA), Faro, Portugal Department of Biomedica...

We assessed ANG II type 1 (AT(1)) and type 2 (AT(2)) receptor (R) expression and functional recovery after ischemia-reperfusion with or without AT(1)R/AT(2)R blockade in isolated working rat hearts. Groups of six hearts were subjected to global ischemia (30 min) followed by reperfusion (30 min) and exposed to no drug and no ischemia-reperfusion (control), ischemia-reperfusion and no drug, and i...

The ubiquitin-activating enzyme E1 (EC 6.3.2.19) represents the first step in the degradation of proteins by the ubiquitin proteasome pathway. E1 transfers ubiquitin from the ubiquitinated E1 to the ubiquitin carrier proteins (E2), ubiquitin-protein ligases (E3) and proteins. This process is rather complex, and known from the work of Haas, Ciechanover, Hershko, Rose and others. The occurrence o...

The aim of the study was to analyze the relation between motor abilities and performance in folk dances originating from the island of Hvar and modern social dances. Two groups of variables were used in a sample of 78 female students of the Teacher Training College from Split: 7 motor variables as a battery of predictors, and performance evaluation of 4 dances (2 folk dances, i.e. ciciliona and...

Carbonated hydroxyapatite (CHA) bone cement is capable of self-setting and forming structures similar to mineralized bone. Conventional CHA leaves little room for new bone formation and delays remodeling. The purposes of this study were to develop porous CHA (PCHA) bone cement and to investigate its physicochemical properties, biocompatibility, biodegradation, and in vivo bone repair potential....

To determine whether intrinsic angiotensin II (ANG II) type 1 receptor (AT1-R) stimulation modulates recovery of postischemic mechanical function, we studied the effects of selective AT1-R blockade with losartan on proton production from glucose metabolism and recovery of function in isolated working rat hearts perfused with Krebs-Henseleit buffer containing palmitate, glucose, and insulin. Aer...

Introduction The exclusive use of a cochlear implant (CI) in one ear allows patients to effectively hear speech in a quiet environment. However, in environments with competing noise, the processing of multiple sounds becomes complex. In an attempt to promote binaural hearing in a noninvasive manner, the use of a hearing aid in the nonimplanted ear is suggested for patients with a unilateral CI....