OBJECTIVES A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both domestic and international references, examined the chemical management system, working environment, level of exposure, and possible associated risks. This information may be utilize...

To clarify the health risks related to silver nanoparticles (Ag-NPs), we evaluated the genotoxicity, acute oral and dermal toxicity, eye irritation, dermal irritation and corrosion and skin sensitisation of commercially manufactured Ag-NPs according to the OECD test guidelines and GLP. The Ag-NPs were not found to induce genotoxicity in a bacterial reverse mutation test and chromosomal aberrati...

The acute and chronic toxicity of zinc to wild mottled sculpin (Cottus bairdi) was measured with 13-d and 30-d flow-through toxicity tests, respectively. Exposure water hardness was 48.6 mg/L as CaCO3 and 46.3 mg/L as CaCO3 in the acute and chronic tests, respectively; pH was slightly above neutral; and temperature near 12 degrees C. The median lethal concentration (LC50) after 96 h was 156 mic...

Acute and chronic toxicity tests were conducted on green mussel (Perna viridis) to determine the adverse effects of lead (Pb). Exposure of organisms to acute toxicity test for 96 h and lethal concentration (LC(50)) was the endpoint of the test. Acute toxicity for 96-h LC(50) and 95% confidence intervals of P. viridis was 2.62 ± 0.12 (2.62-3.24) mg/L Pb. Chronic toxicity tests revealed that surv...

A survey conducted on the EU Notification of New Substances (NONS) database suggested that for industrial chemicals with a profile of low toxicity in (sub)acute toxicity tests there is little added value to the conduct of the 90-day repeated dose study. Avoiding unnecessary animal testing is a central aim of the EU REACH chemicals legislation; therefore we sought to verify the profile using add...

Background: Rhabdomyolysis is one of the major complications of poisoning caused by alcohol, narcotics, and psychotropic substances acute toxicity, which might lead to acute renal failure and even death. This study aimed to evaluate clinical and laboratory findings of rhabdomyolysis syndrome in poisoning patients who were admitted to poisoning ward of Farshchian Hospital of Hamadan, Iran. Meth...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decrea...

persea americana is a plant used by traditional medicine practitioners to treat ailments including diarrhoea and diabetes mellitus in nigeria. hence, the chloroform and the methanol fractions of the chloroform-methanol extract of the leaves of p. americana were evaluated for their acute toxicity as well as anti-diarrhoeal effects in wistar rats to substantiate this claim. the chloroform and met...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decreas...