Objective(s): Our previous studies have shown that MgO nanoparticles (MgO NPs) could improve anxiety and reduce pain in animals. In this study, the effect of co administration MgO NPs and vitamin C on anxiety like behavior and nociception in postpartum depression (PPD) model were investigated.Materials and Methods:  Female mice (27 ± 3 g) were divided into groups: two control groups, PPD groups...

Objective With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (e.g., pain intensity) and...

Background.  Many mechanisms are involved in pain transmission in the spinal cord.  Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia.  We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...

acute chest pain is an important and frequently occurring symptom in patients. chest pain is often a sign of ischemic heart disease. chest pain due to suspected acute coronary syndrome (acs) is responsible for a large and increasing number of hospital attendances and admissions. current practice for suspected acs involves troponin testing 10–12 hours after symptom onset to diagnose myocardial i...

background and objectives non-traumatic acute abdominal pain is one of the most common complaints in patients referred to emergency department. to make diagnosis decision several diagnostic tests such as wbc count, urine analysis, and abdominal sonography are usually ordered which disturb emergency department, staff and force significant cost to patient and are time consuming. this study was do...

abstract   background: sacroiliac joint (sij) dysfunction is a widely known but poorly defined   cause of low back pain. to our knowledge, few published studies have been   conducted to evaluate systematically the prevalence and significance of concomitant   sacroiliac joint dysfunction in patients with herniated lumbar discs. as concomitant   sij dysfunction in low back pain patients is likely...

abstract   background: sacroiliac joint (sij) dysfunction is a widely known but poorly defined cause of low back pain. to our knowledge, few published studies have been conducted to evaluate systematically the prevalence and significance of concomitant sacroiliac joint dysfunction in patients with herniated lumbar discs. as concomitant sij dysfunction in low back pain patients is likely to resp...

Since use of antinoceceptive chemical drugs for relief of pain has many side effects, medical plants seem very noticeable today. Previous findings indicate that Carum Carvi (CC) modulates pain in both animal and human. The present work investigated the effects of hydoalcoholic extract of CC on acute pain in Hot plate and Tail flick models. Albino mice (20-30 g) were used for this study. Hydroal...