Relevance: Kidney functions in treating acute myeloblastic leukemia (AML) undergo serious effects, especially elderly patients. Chemotherapeutic drugs used to prepare for hematopoietic stem cell transplantation (HSCT) inevitably affect patients’ kidney function. Moreover, involutive changes the kidneys can physiologically decrease function.
 The study aimed evaluate function an patient wit...

Congenital leukemia is a very rare malignancy of childhood with a poor prognosis. The incidence is nearly 1 in 5 million live births. The majority of cases are acute myeloblastic leukemia with trisomy. Clinical manifestations are usually leukocytosis, petechia, ecchymosis, cutaneous nodules, hepatosplenomegaly and central nervous system symptoms. 23-days old girl was presented with complaints o...

Introduction: Nowadays, a significant number of children with acute leukemia can be cured. Iron overload, related to blood transfusions and its long-term complications, remains problem. Elevated ferritin concentration is often observed in this group. The aim study was evaluate the prognostic value serum on outcomes treated for leukemia. Material: We studied 71 patients lymphoblastic (ALL) or my...

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disorder in which the blood cells demonstrate aberrant interactions with serum complement. In part, this is due to the absence of the complement regulatory protein, decay accelerating factor (DAF). A small number of patients with PNH have gone on to develop acute nonlymphocytic leukemia, which is thought to arise f...

The introduction of combination chemotherapy in the treatment of adult acute leukemia has had a profound impact on the response and duration of survival of patients with adult acute myeloblastic leukemia. In the past decade, the combination of cytosine arabinoside with an anthracycline antibiotic, either daunorubicin, adriamycin, or rubidazone, has been responsible to a large degree for the suc...

The etiology of cerebral hemiatrophy may be congenital or acquired. Trauma, infection, vascular abnormality, ischemic and hemorrhagic conditions may be the etiologic factors in acquired type. There is limited information about its association with other disorders in the literature. We presented three new cases of cerebral hemiatrophy associated with some hematological and developmental disorder...

Mucormycosis is a rare complication in cancer patients. This report presents the case of a acute myeloblastic leukemia patient who developed an ascending paralysis due to disseminated mucormycosis. The presentation was unusual because the early symptoms were fever and pain, and the disease was misdiagnosed because of a concomitant infection by Enterococcus faecium.

The nitroblue tétrazolium (N B T ) test is most useful for the diagnosis of chronic granulomatous disease and a few other rare metabolic abnormalities of neutrophils. It may be helpful in suggesting the presence of infection when values of both percentage of N BT positive neutrophils and total number of N BT positive neutrophils are markedly increased. Each patient must be inter­ preted with ca...

The phenomenon of premature chromosome condensation (PCC) was used to compare the bone marrow proliferation characteristics of 163 patients with various forms of leukemia prior to the initiation of new therapy. The proliferative potential index (PPI, or fraction of G1 cells in late G1 phase) and the fraction of cells in S phase was determined and compared to the type of disease and the bone mar...