Simon's two-stage designs are very popular for phase II clinical trials. A literature review revealed that the inference procedures used with Simon's designs almost always ignore the actual sampling plan used. Reported P-values, point estimates and confidence intervals for the response rate are not usually adjusted for the design's adaptiveness. In addition, we found that the actual sample size...

of motifs from pagan healing cults by the Christians, and it is good to have a further archaeological demonstration of the same point. This rivalry may go some way to explain the total destruction at Pergamum of all artistic representations of Asclepius of Pergamum, for which we have to rely on statues and coins from Thrace and the Black Sea region and on the late testimony of an Arabic scholar...

yield gap analysis provides an essential framework to prioritize research and policy efforts aimed at reducing yield constraints. to identify options for increasing chickpea yield, the ssm-chickpea model was parameterized and evaluated to analyze yield potentials, water limited yields and yield gaps for nine regions representing major chickpea-growing areas of razavi khorasan province. the aver...

Manufacturing performances tend to produce defects due to various reasons which can be improved by identifying and eliminating them using six sigma. In the present work, DMAIC (Define, Measure, Analyze, Improve and Control) has been used to reduce the number of vehicle engine rejection. In define phase problem was defined by selecting the core issues concerned. In the measure phase data was col...

  Background: Educational clinical environment has an important role in nursing students' learning. Any difference between actual and expected clinical environment will decrease nursing students’ interest in clinical environments and has a negative correlation with their clinical performance.   Methods : This descriptive cross-sectional study is an attempt to compare nursing students'perception...

Four theories proposing determinate relations of actual causation for Boolean networks are described and applied to 16 cases. All four theories are founded on the idea that actual causation is based on results that appropriate experimental interventions would produce. They differ in their accounts of the relevant kinds of experimental interventions. The more complex theories are motivated by tr...

In 1964 José Benardete invented the “New Zeno Paradox” about an infinity of gods trying to prevent a traveller from reaching his destination. In this paper it is argued, contra Priest and Yablo, that the paradox must be resolved by rejecting the possibility of actual infinity. Further, it is shown that this paradox has the same logical form as Yablo’s Paradox. It is suggested that constructivis...

Ecopa, the European Consensus Platform on alternatives, is an international not-for-profit organization, based in Belgium and complying with Belgium law. It is the only quadripartite organization at EU level, which is promoting the 3R-Alternatives at the European level. Ecopa brings together National Consensus Platforms on alternative methods. Consensus means that all parties concerned are repr...