نتایج جستجو برای: activation receptor
تعداد نتایج: 919194 فیلتر نتایج به سال:
Introduction: N-methyl-D-aspartate (NMDA) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. Activation of NMDA receptors involves the induction of long term potentiation (LTP) in hippocampus. Our previous study suggested that chronic oral administration of morphine enhanced NMDA dependent LTP in the CA1 area of hippocampal slices of rats. The p...
Background: People are exposed to more radiation than before with the application of radiation technology. Radiation is known to induce damage to cell structure, DNA, chromosomes and nucleus. In this study, we showed that CGJ extract can inhibit radiation-induced chromosomal damage in vivo and NLRP7 inflammasome activation in vitro, suggesting that the compound from CGJ can Be considered as a t...
Natural Killer (NK) cells are the main lymphocyte population expressing P75 B chain of the IL-2 receptor (IL-2R). Consequently, incubation of peripheral blood lymphocytes with IL-2 induce selective activation of NK cells and results in NK activity and generation of Lymphokine activated killer (LAK) cells activity and proliferation. One of the early events during IL-2 activation of peripheral bl...
Abstract Noses are extremely sophisticated chemical detectors allowing animals to use scents interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating mucosa. Different odorants, or different concentrations same odorant, activate unique ensembles ORs. This mechanism combinatori...
chronic pain is a prevalent and debilitating condition, conveying immense human burden. suffering from chronic pain is not only caused by painful symptomatology, but also through a wide range of psychopathological and physical consequences, including depression and anxiety disorders, impaired sleep and cognition, cardiovascular morbidity and impaired sexual function, all contributing to diminis...
Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible ligands are small nuclear (snRNA) endogenous retroviral elements (ERV) leaking from nucleus during programmed cell death.
Abstract Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the β-catenin/TCF transcription complex consequent regulation a set downstream genes. DKK1 has been shown to be potent inhibitor via competing binding LRP5/6. is tumorigenic multiple cancer types also immunosuppressive MDSCs NK cells. Emerging evidence...
introduction: previous studies have shown that cannabinoidergic system is involved in anxiety. however, there are controversial reports in the experimental studies. the aim of this study is to evaluate the effect of pharmacological stimulation or blocking of cb1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (epm) test in rat. the epm is o...
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