Many airway sensory units respond to both lung inflation and deflation. Whether those responses to opposite stimuli come from one sensor (one-sensor theory) or more than one sensor (multiple-sensor theory) is debatable. One-sensor theory is commonly presumed in the literature. This article proposes a multiple-sensor theory in which a sensory unit contains different sensors for sensing different...

Peroxisome proliferator-activated receptors are nuclear receptors that were isolated for their ability to modulate lipid metabolism. Similar to other members of the nuclear receptor family, peroxisome proliferator-activated receptors bind ligand as heterodimers and exert their effects via transcriptional regulation through their DNA binding domains. During the past decade, it has become clear t...

Vasopressin (AVP) and oxytocin (OT) receptors (nomenclature as recommended by NC-IUPHAR [94]) are activated the endogenous cyclic nonapeptides vasopressin oxytocin. These peptides derived from precursors which also produce neurophysins (neurophysin I for oxytocin; neurophysin II vasopressin). differ at only 2 amino acids (positions 3 8). There metabolites of these neuropeptides that may be biol...

Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [119]) are activated endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10,13,16-enoylethanolamine and 2-arachidonoylglycerol. Potency determinations of agonists at these complicated possibility differential susceptibility to enzymatic c...

The perception of taste is a prime example complex signal transduction at the subcellular level, involving an intricate network molecular machinery, which can be investigated to great extent by tools provided Computational Molecular Modelling. present review summarises current knowledge on mechanisms root transduction, in particular receptors, highly specialised proteins driving activation/deac...

1Vascular Biology Program, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA 2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 3Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada T2N 4N1 4 Institute for Biocomplexity and Informatics, University of Calgary, Calgary, AB, Ca...