garlic and onions as dietary constituents and medicines have been used for many disorders which dates back to the early civilization. it has been shown that different species of allium have immunomodulating effects. in this study, we sought to determine if methanolic and chloroformic extracts of allim fistulosum l. (leek) have any effect on cell-mediated immune response in mice. methanolic and ...

Subcutaneous injection of exogenous insulin or insulin analogues needs to be performed one or more times daily for type 1 diabetics. The timing and dosage of insulin administration have been a critical research area since the invention of insulin analogues. Several mathematical models have been proposed and some are applied clinically in modeling various insulin therapies. However, these models...

The skin actively contributes to host defense by mounting an innate immune response that includes the production of antimicrobial peptides. These peptides, which include but are not limited to the cathelicidin and defensin gene families, provide rapid, broad-spectrum defense against infection by acting as natural antibiotics and by participating in host cell processes involved in immune defense...

Mixed hepatitis C virus (HCV) genotype infection is emerging with improved methods of detection. It is commonly seen in hemodialysis patients and intravenous drug users due to repeated HCV exposure and absence of protective immunity, and can contribute to treatment failure. Direct-acting antiviral regimens have been extensively studied in patients with different individual HCV genotypes; howeve...

This study reviews opiates (endorphin agonists) in treatment of pain and addiction with specific focus on their addictive potential versus benefits. This review suggests endorphin agonists enjoy mood stabilizing and antidepressant properties and have been helpful in treatment of pain, mood and addictive disorders. The evidence is consistent with the observation that slow release opiate preparat...

Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens. The dual implication of key cellular functions in the inna...

background: cigarette smoking has been linked with the suppression of immune responses and increased susceptibility to numerous infections in humans. tetanus is also a major public health problem in many countries. the aim of the present study was to evaluate the serum levels of anti-tetanus toxin antibodies in c igarette smoking and healthy non-smoking people .   materials and methods: a total...

background: the increasing incidence of pertussis among adolescents and adults in recent years is an alarming factor in transmission of the infection to non-immune infants and children. vaccination of pregnant women, immediately after delivery and before being discharged from the hospital may help to protect mothers and their newborns against the disease. decision making process, regarding mate...

background: our information regarding immunity to toxoplasmosis among reproductive age women is indeterminate and there is significant variation between reported results; it is necessary to perform a meta-analysis study on subjects to obtain required findings and develop preventive measures accordingly. objective: estimation level of immunity to toxoplasmosis in reproductive ages. materials and...

The frequency of adaptive evolution acting on common loci in distant lineages remains an outstanding question in evolutionary biology. We asked whether the immunity factor, Relish, a gene with a history of directional selection in Drosophila simulans, shows evidence of a similar selective history in other Drosophila species. We found only weak evidence of recurrent adaptive protein evolution at...