We describe the first Gquadruplex targeting approach that combines an intercalation and a hybridization strategy by investigating the interaction of a G-rich PNA acridone conjugate 1 with a three repeat fragment of the human telomere G3 to form a hybrid PNA-DNA quadruplex mimicking the biologically relevant (3+1) pure DNA dimeric telomeric quadruplex. Using a combination of UV, CD and fluoresce...

THE TITLE ACRIDONE ALKALOID [SYSTEMATIC NAME: 1,3,5-trihydr-oxy-2,4-bis-(3-methyl-but-2-en-yl)acridin-9(10H)-one], C(23)H(25)NO(4), known as atalaphylline, was isolated from Atalantia monophylla Corrêa, a mangrove plant. The mol-ecule contains three fused planar rings with an r.m.s. deviation of 0.026 (2) Å. Both 3-methyl-but-2-enyl substituents are in a (-)anticlinal conformation. An intra-mol...

Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy...