Acridine derivatives constitute a class of compounds that are being intensively studied as potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is limited or even excluded because of side effects. Numerous synthetic methods are focused on the preparation of target acridine skeletons or modifications of naturally occurring co...

As a first step in the synthesis and the study of DNA polyintercalating drugs, dimers of acridines have been prepared. Their DNA binding properties have been studied. It has been determined that when the chain separating the two aromatic rings is longer than a criticål distance, bisintercalation is actually observed and that the DNA binding affinity becomes quite large (greater than 10(8)-10(9)...

概要 造 血臓器 の体外 組織培 養 を蛍光 色素acridine orangeで 染 色 し,蛍光顕微鏡 で観察 する方 法(蛍 光培養 法)を 案 出 し,広 く臨床 に応用 して,主 として白血病の 診断に役立 たせ ようと した.骨 髄,リ ンパ節,さ らに腹腔 鏡直視 下に生検 して得た脾組織 片 を平木式培 養盤 で培 養 し,acridine oramgeを 培 地濃 度1万倍 とな るよう加 えた.正 常人骨髄,脾 お よび リンパ節の培 養増生帯は 中心部 が密で,周 辺 に向っ て漸 次疎 とな り,骨 髄では顆 粒 球の蛍 光 に より赤 澄色を,脾,リ ンパ節 では リンパ球 に より黄 緑 色 を呈 した.白 血 病の各臓器 の増生帯 は非 常に稠密 で,辺 縁が鋭利 に区画 され,幼若細 胞の蛍光 に よ りび まん 性緑 色を呈 し,放 熟細胞が混 在す...

Pyrimidoacridinetriones (PATs) are a new group of highly active antitumor compounds. It seems reasonable to assume that, like for some other acridine derivatives, intercalation into DNA is a necessary, however not a sufficient condition for antitumor activity of these compounds. Rational design of new compounds of this chemotype requires knowledge about the structure of the intercalation comple...

An efficient ligand-promoted biomimetic aerobic oxidative dehydrogenative cross-coupling between arenes and nonbiased olefins is presented. Acridine as a ligand was found to significantly enhance the rate, the yield, and the scope of the reaction under ambient oxygen pressure, providing a variety of alkenylarenes via an environmentally friendly procedure.

Oligonucleotide conjugates containing acridine and quindoline derivatives linked through a threoninol molecule were synthesized. We showed that these conjugates formed duplexes and quadruplexes with higher thermal stability than the corresponding unmodified oligonucleotides. When acridine is located in the middle of the sequence, DNA duplexes have a similar stability independently of the natura...

The effect of non-radiative energy transfer and diffusion on the fluorescence decay of phenanthrene in the presence of acridine was observed in six solvents of viscosity 7 = 0.4 CP to 64.6 CP. The system obeys Stem-Volmer kinetics at low 7, Forster kinetics at high 7 and intermediate kinetics at medium 7. At 7 = 64.6 CP the decay obeys the Forster relation. At lower 7 it agrees satisfactorily w...