Acne and rosacea are both highly prevalent inflammatory skin diseases that characterized by erythema, papules, pustules, primarily involving the pilosebaceous units of face, yet with distinct mechanisms disease pathogenesis. Here, we used single-cell RNA-sequencing (scRNA-seq, n=22) spatial imaging (CosMx, n=4) to compare gene expression individual cells in acne vs. lesions elucidate pathways p...

Christos C. Zouboulis, Qiang Ju, and Lei-Hong Flora Xiang Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany; Department of Dermatology, Renji Hospital, Jiaotong University School of Medicine, Shanghai, P.R. China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China

THE object of this paper is to set out shortly some of the etiological factors in acne vulgaris, and to indicate the bearing which they have on treatment. It is, unfortunately, often regarded as a condition about which nothing is known, and to which treatment makes very little difference; and patients are too frequently told that they must just wait until it disappears. Acne is so common as to ...

INTRODUCTION Cutaneous tuberculosis (TBC) is a chronic disease caused by Mycobacterium tuberculosis, and is present in less than 1-2% of all TBC cases. The current problem with diagnosis is the demonstration of bacillus in the skin, especially paucibacillar forms, where sources like polymerase chain reaction (PCR) have improved diagnostic capacity. CASE PRESENTATION Two cases of cutaneous TBC...

O cular rosacea, a disease often associated with acne rosacea, can present with a variety of clinical features, which are often nonspecific. However, in about one-third of cases, it may occur as an isolated entity without skin involvement. Appropriate diagnosis and management is essential as potentially sight-threatening corneal involvement can occur in a significant number of patients if the c...

BACKGROUND Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinica...

Demodex mites may induce inflammatory cutaneous reactions such as papulopustular rosacea and demodex folliculitis; both may lead to post inflammatory pigmentation. A 59-year-old man presented with an asymptomatic, hyperpigmented plaque on his face. Histological and clinical findings displayed Riehl-like facial pigmentation. Multiple demodex mites at the follicular infundibulum in the biopsy mat...