We report herein the synthesis of new derivatives dihydropyrimidine on basis 2,4,6-trimetoxybenzaldehyde, which was further regioselectively oxidized in presence cerium ammonium nitrate (CAN) with formation 5-acetyl-6-methyl-4-(2,4,6-trimethoxyphenyl)pyrimidin-2(1H)-one. The structures both novel compounds were investigated by NMR, mass spectroscopy methods. structure compound 4 also X-ray sing...

Predatory behavior, a property associated with ecosystems, is not commonly observed in microorganisms. However, cannibalistic tendencies have been observed in microorganisms under stress. For example, pure culture of Bacillus subtilis exhibits cannibalism under nutrient limitation. It has been proposed that a fraction of cells in the population produce Spo0A, a regulatory protein that is respon...

Heat stroke is a potentially fatal disorder that's caused by an extreme elevation in body temperature. We report here an unusual case of multiple organ failure that was caused by classical, nonexertional heat stroke due to taking a warm bath at home. A 68 year old diabetic man was hospitalized for loss of consciousness. He was presumed to have been in a warm bath for 3 hrs and his body temperat...

Untreatable bacterial infections (“the post-antibiotic era”) are far more likely to emerge in companion animals than in food animals, and have already arrived in the form of the multi-drug resistant (MDR) ESKAPE pathogens, the scourge of hospitals. These highly resistant, and in some cases hospital-adapted pathogens, are Enterococcus faecium, methicillin-resistant Staphylococcus pseudintermediu...

Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has been determined, showing significant differences in the substrate binding cavity when compared to the pyrazinamidases from Pyrococcus horikoshii and Acinetobacter baumanii. In M. tuberculosis, this region was found to hol...

In recent decades, emerging bacterial resistance is defying the efficacy of currently available antibiotics. Of the approximate 1.7 million hospital acquired infections in the US annually, a staggering 350,000 infections can be attributed to just a few multi-drug resistant pathogens [1-3]. Current consensus indicates Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobac...