this paper summarizes the proceedings of a 1 day national symposium entitled “reproductive biology, stem cells biotechnology and regenerative medicine” held at shahid sadoughi university of medical sciences, yazd, iran on 3rd march 2016. here, we collected the papers that presented and discussed at this meeting by specialists that currently researched about the overlaps of the fields of reprodu...

objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

multiple sclerosis (ms) is an autoimmune inflammatory demyelinating disease of the central nervous system. the aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (ucb-msc) derived neural progenitor cell (mdnpc) in eae, an experimental model of ms. to initiate neuronal differentiation of ucb-mscs, the pre-inductio...

introduction: transplantation of bone marrow stromal cells (bmscs) or schwann cells (scs) can increase axonal regeneration in peripheral nerve injuries. based on our previous investigations, the goal of the present work was to examine the individual and synergistic effects of the two different cell types in sciatic nerve injury . we pursued to evaluate the effects of bmscs and scs co-transplant...

INTRODUCTION Acromegaly is frequently associated with impaired glucose tolerance and/or diabetes. To evaluate the relationship between glucose metabolism and acromegaly disease, we evaluated 269 consecutive patients from two referral centres. METHODS Clinical presentation, pituitary tumor size and invasiveness, and pituitary pathology were captured in a dedicated database. RESULTS 131 women...

Abstract Introduction Growth hormone (GH) and prolactin co-secreting pituitary adenoma is the most common type of pleuri-hormonal adenomas. We present a case GH macroadenoma with somato-mammotroph (SMT) histopathology. Case A 48-year-old female presented complaints chronic headaches coarsening facial features for >5 years. Associated symptoms included fatigue, joint pain, heat intoleranc...

A 66-year-old woman with acromegaly and diabetes mellitus as well as primary hyperthyroidism is described. Serum GH Levels were inappprpriately high.MRI revealed an enlarged sella turcica with intrasellar mass. Her HbAlc was 12.2% and fasting blood glucose 8.89 mmol/l. Thyroid hormone levels in serum and thyroidal radioiodine uptake values were elevated, while TSH measurements in serum were low...

Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1 α -inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β -catenin-activated HCA (b-HCA). We reviewed retrospectively our surgical HCA series to learn how to recognize the different subtypes histopathologically and how to interpret adequately their immunohistochemical staining. From Janua...

The adrenal glands were first described in 1552 by the Italian anatomist Bartolomeo Eustachi in his Opuscula Anatomica as ‘‘glandulae renis incumbentes’’ (glands lying on the kidney) [1], but their function remained controversial for the next 300 years [2]. The adrenal have a dual origin (Fig. 2.1a, b), i.e. the cortex arises from mesoderm whereas the medulla has a neuroectodermal origin [2]. T...