Cell survival is conditional on the maintenance of a favourable acid-base balance (pH). Owing to intensive respiratory CO2 and lactic acid production, cancer cells are exposed continuously to large acid-base fluxes, which would disturb pH if uncorrected. The large cellular reservoir of H(+)-binding sites can buffer pH changes but, on its own, is inadequate to regulate intracellular pH. To stabi...

An agar plate method has been developed for the rapid, preliminary screening of large numbers of rhizobia for tolerance to acidity and aluminum (acid-Al). Media containing pH indicators are used, and distinguish true tolerance from cases where growth depends on a previous pH shift. Strains which were highly tolerant or sensitive to acid Al on agar behaved similarly in defined liquid media. Stra...

The most comprehensive solvent acidity scale spanning 28 orders of magnitude of acidity was measured in the low-polarity solvent 1,2-dichloroethane (DCE). Its experimental core is linked to the unified acidity scale (pHabs) in an unprecedented and generalized approach only based on experimental values. This enables future measurements of acid strengths and acidity adjustments in low polarity so...

Several years ago experiments by one of us pointed to a lack of correspondence between blood acidity and pulmonary ventilation, which seemed to contradict the generally accepted view that the acidity of the arterial blood controlled respiration. These experiments (1) led to the statement that “The conception that the hydrogen ion concentration of the arterial blood regulates respiration is anal...

Larvae of Psychoda and of Chironomus (diptera) maintained in solutions of appropriate indicators show that the typical acidities (pH) prevailing within the several regions of the digestive tract are: esophagus 7.1; cardiac chamber 6.2; mesenteron 7.5; the latter being functionally an intestine. The acidity of the hindgut, pH 6.4, is due to the discharge of the malphigian tubules.

Peptic ulcer is common in present days due to stress and anxiety. Peptic ulcer is thought to result from an imbalance between acid-pepsin secretion and mucosal defense factors. Though currently available drugs provide adequate relief from pain, promote healing, the problem of relapse has eluded success. The present study was designed to evaluate the combination effect of melatonin with lansopra...

The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. The extract was preliminary evaluated for acute oral toxicity test using Organisation for Economic Co-operation and Development guidelines 423. Further, it was studied for antiulcer...

Acid and metalliferous drainage (AMD) is broadly accepted to be a major global environmental problem facing the mining industry, requiring expensive management and mitigation. A series of laboratory-scale kinetic leach column (KLC) experiments, using both synthetic and natural mine wastes, were carried out to test the efficacy of our pyrite passivation strategy (developed from previous research...

Omeprazole plus amoxicillin cures Helicobacter pylori infection. The hypothesis was tested that low acidity is a predictor of outcome. Fifty patients with relapsing or complicated, or both H pylori positive duodenal (n = 25) or gastric ulcer (n = 25) were randomly treated with either omeprazole 20 mg twice daily plus amoxicillin 1 g twice daily or with omeprazole 40 mg twice daily plus amoxicil...