The ultrasound-induced cleavage of covalent and non-covalent bonds to activate drugs (sonopharmacology) is a promising concept gain control over the action active pharmaceutical ingredients by an external trigger. Previously, linear polymer architectures bearing drug payloads were exploited for release using principles mechanochemistry. In this work, carrier design altered topology improve ultr...

Hyperpolarized [1-13C]fumarate is a promising magnetic resonance imaging (MRI) biomarker for cellular necrosis, which plays an important role in various disease and cancerous pathological processes. To demonstrate the feasibility of MRI metabolism using parahydrogen-induced polarization (PHIP), low-cost alternative to dissolution dynamic nuclear (dDNP), cost-effective high-yield synthetic pathw...