In a controlled seven week stndy in ten patients with chronic obstructive bronchitis, nebnlized N-acetylcysteine combined with racemic epinephrine was highly effective in thinning sputum. By contrast, nebulized saline plus racemic epinephrine tended to make the sputum thicker in these same patients. Neither the N-acetylcysteine-racemic epinephrine combition nor the salineracemic epinephrine aer...

Title: The effectiveness of antioxidant drugs such as N-acetylcysteine and Ozone on the stasis zone. Short title: Effectiveness Purpose: Stasis zone, zone around coagulation is important for prevention necrosis in burns. Various were studied literature to prevent previous researches have shown Nacetylcysteine treatment both remote organs local side thermal injury. Demonstration N acetylcysteine...

background: acetaminophen (n-acetyl-p aminophenol; apap) is one of the most common types of analgesics. it is also the most common xneobitic reported to poison centers. this study investigates if therapeutic doses of nac can falsely increase coagulation tests, prothrombin time (pt) and bleeding time (bt). ​​ methods: thirty-six apap poisoned patients whose acetaminophen serum concentration were...

STUDY OBJECTIVE To compare outcomes after acute acetaminophen poisoning in 2 large cohorts of patients treated with either the 20-hour intravenous or 72-hour oral acetylcysteine protocol. METHODS We conducted a retrospective cohort study with historical control comparing patients treated with one of 2 acetylcysteine regimens. Data for the 20-hour group were obtained from a medical record revi...

OBJECTIVE Experimental studies have shown that acetylcysteine is beneficial in preserving kidney function during coronary procedures. However, its role in routine clinical practice is not known. METHODS We studied 75 consecutive patients undergoing coronary procedures who received acetylcysteine, and compared them with 56 consecutive similar patients who served as control. All patients had re...

Increasing the urinary output of free thiol groups protects against cyclophosphamide-induced bladder toxicity. In the present study, intact rats, isolated perfused kidneys, and freshly isolated cells from various rat organs are used to compare the efficacy of N-acetylcysteine and sodium 2-mercaptoethane sulfonate (mesna) as sources of urinary thiols. In intact rats given a single i.v. dose of m...

Since the introduction in 1979 of intravenous acetylcysteine (Parvolex) as an antidote for overdosage of paracetamol the National Poisons Information Service and the manufacturer have been notified of 38 adverse reactions that were anaphylactoid in nature and 19 accidental overdoses. The most common feature of the anaphylactoid reaction to normal dosage was rash; other features reported include...

Idiopathic pulmonary fibrosis (IPF) is still a non-curable disease. The suggested therapy consists of Pirfenidone combined with other drugs like azathioprine, and acetylcysteine. The New England Journal of Medicine published a new study that goes against the common use of N-acetylcysteine (NAC) to treat IPF patient. There are other studies that went in favor of N-acetylcysteine. The present stu...

Acetaminophen poisoning remains one of the more common drugs taken in overdose with potentially fatal consequences. Early recognition and prompt treatment with N-acetylcysteine can prevent hepatic injury. With acute overdose, the Rumack-Matthew nomogram is a useful tool to assess risk and guide management. Equally common to acute overdose is the repeated use of excessive amounts of acetaminophe...

1383–8. 7. Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent–induced reductions in renal function by acetylcysteine. N Engl J Med 2000;343: 180–4. 8. Durham JD, Caputo C, Dokko J, et al. A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int 2002;62:2202–7. 9. Allaqaband ...