نتایج جستجو برای: acetylcholinesterase alzheimer
تعداد نتایج: 21439 فیلتر نتایج به سال:
A new family of dual binding site acetylcholinesterase (AChE) inhibitors has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), AChE-induced and self-induced β-amyloid (Aβ) aggregation and β-secretase (BACE-1), and to cross the blood-brain barrier. The new heterodimers consist of a unit of racemic or enantiopure huprine Y or X and a donepezil...
Alzheimer᾽s disease is characterized by cognitive deficits, impaired long-term potentiation of learning and memory. A progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in Alzheimer's disease (AD). In the current project a new series of phthalimide derivatives were synthesized. Phthal...
Galantamine is a natural product belonging to the isoquinoline alkaloid family of compounds. It was first discovered and isolated in the 1950s from Galanthus nivalis (common snowdrop) and Galanthus woronowii (Caucasian snowdrop), members of the Amaryllidaceae family (Marco and do Carmo Carreiras, 2006). Alzheimer’s disease (AD) is named after Dr. Alois Alzheimer, who first identified the diseas...
Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaol-huprine hybrids, purported to hit several key targets involved in Alzheimer's disease. The hybrids have been tested in vitro for their inhibitory activity against human acetylcholinesterase and butyrylcholinesterase and an...
Recently Nutrition and Food Chemistry researches have been focused on plants and their products or their secondary metabolites having anti-alzheimer, anti-cancer, anti-aging, and antioxidant properties. Among these plants Salvia L. (Lamiaceae) species come into prominence with their booster effects due to high antioxidant contents, which have over 900 species in the world and 98 in Turkey. Some...
Recently Nutrition and Food Chemistry researches have been focused on plants and their products or their secondary metabolites having anti-alzheimer, anti-cancer, anti-aging, and antioxidant properties. Among these plants Salvia L. (Lamiaceae) species come into prominence with their booster effects due to high antioxidant contents, which have over 900 species in the world and 98 in Turkey. Some...
Từ hoa mai vàng, một dihydroflavonol glucoside đã được phân lập và khảo sát các hoạt tính sinh học. Cao ethyl acetate (cao EA) của vàng có học rất tốt như là chất kháng oxy hóa với IC50 2,27 µg/mL, (gấp 2 lần đối chứng acid ascorbic) ức chế enzyme α-glucosidase giá trị = 0,22±0.05 µg/mL (mạnh hơn 800 Acarbose). EA chủng vi khuẩn Gram dươngC50 136,0±3,09 µg/mL). Cấu trúc hợp từ cao làm sáng tỏ b...
Among the Mediterranean aromatic plants, Ruta tuberculata Forssk. (Rutaceae) has been widely used as a traditional natural remedy against various disorders resulting from its divers’ pharmacological virtues. The aim of this study is to characterize for first time phenolic profile ethyl acetate (EtOAcE) and acetonic (AcE) extracts screen their in vitro antioxidant, antidiabetic, neuroprotective ...
During November 2012-July 2013, a marked increase of adenovirus type 7 (Ad7) infections associated with severe disease was documented among pediatric patients in Singapore. Phylogenetic analysis revealed close genetic links with severe Ad7 outbreaks in China, Taiwan, and other parts of Asia.
Plant-based remedies have been widely used for the management of variable diseases due to their safety and less side effects. In present study, we investigated Saussurea lappa CB. Clarke. (SL) given its largely reported medicinal Specifically, our objective was provide an insight into a new polymethyl methacrylate based nanocapsules as carriers SL essential oil characterize biologic functions. ...
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