نتایج جستجو برای: acetylcholine ach
تعداد نتایج: 28165 فیلتر نتایج به سال:
Hypocretin/orexin neurons regulate many behavioral functions, including addiction. Nicotine acts through nicotinic acetylcholine receptors (nAChRs) to alter firing rate of neurons throughout the brain, leading to addiction-related behaviors. While nAChRs are expressed in the hypothalamus and cholinergic fibers project to this structure, it is unclear how acetylcholine modulates the activity of ...
The snail acetylcholine binding protein (AChBP) is homologous to the extracellular domains of the nicotinic ACh receptors. In this issue of Neuron, Celie et al. show how the crystal structures of AChBP in complexes with carbamylcholine and nicotine reveal the basis for agonist recognition by ACh receptors.
The action of electrical stimulation of one of the pallial nerves on the sensitivity of the bursting RPa1 neuron of Helix pomatia to acetylcholine (ACh) was investigated. The depolarizing effect of ACh was significantly decreased by presynaptic stimulation. Stimulation leads also to an attenuation of the ACh-induced increase in membrane conductivity. The effect of stimulation on the ACh evoked ...
Platelet-activating factor (PAF), a potent signaling lipid implicated as a mediator of pathological responses, has both negative chronotropic and inotropic effects on the heart, although the mechanism(s) involved is not well defined. Because activation of the muscarinic acetylcholine-activated K+ current (IK(ACh)) also produces a negative chronotropic and inotropic response in myocardium, this ...
Hypocretin/orexin neurons regulate many behavioral functions, including addiction. Nicotine acts through nicotinic acetylcholine receptors (nAChRs) to alter firing rate of neurons throughout the brain, leading to addictionrelated behaviors. While nAChRs are expressed in the hypothalamus and cholinergic fibers project to this structure, it is unclear how acetylcholine modulates the activity of h...
BACKGROUND The experience of early stress contributes to the etiology of several psychiatric disorders and can lead to lasting deficits in working memory and attention. These executive functions require activation of the prefrontal cortex (PFC) by muscarinic M1 acetylcholine (ACh) receptors. Such Gαq-protein coupled receptors trigger the release of calcium (Ca(2+)) from internal stores and elic...
An important step for cholinergic transmission involves the vesicular storage of acetylcholine (ACh), a process mediated by the vesicular acetylcholine transporter (VAChT). In order to understand the physiological roles of the VAChT, we developed a genetically altered strain of mice with reduced expression of this transporter. Heterozygous and homozygous VAChT knockdown mice have a 45% and 65% ...
Purpose To investigate the possible antiapoptotic effect of acetylcholine (ACh) in Fas-mediated apoptosis of primary human keratocytes in vitro, and to explore the underlying mechanism. Methods Primary human keratocytes were isolated from healthy corneas. Fas ligand (FasL) was used to induce apoptosis in keratocytes. Cell death was assessed by ELISA. Activity of caspase-3, -7, -8, and -9 was ...
The somatosensory neocortex processes extrinsic information from the thalamus and intrinsic information from local circuits. We compared the effects of acetylcholine (Ach) on neocortical field potential responses evoked by stimulation of the whiskers and by local electrical stimulation in the upper layers of the neocortex vibrissae representation ("barrel cortex") of adult rats anesthetized wit...
Acetylcholine (ACh) was viewed as the “vagusstoff” after Loewi`s experiment with the frog heart [1]. In 1936 Otto Loewi, and Henry Dale were recipients of the Nobel Prize in Physiology and Medicine, by their contribution for the acetylcholine discover as a neurotransmitter [1]. So, ACh was regarded as a neurotransmitter during several decades [2]. After that it was evidenced a widespread expres...
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